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Anti-FGFR1/CD331 Antibody

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Catalog No. T9901A-1357

Anti-FGFR1/CD331 Antibody is a humanized monoclonal antibody targeting fibroblast growth factor receptor 1 (FGFR1/CD331). FGFR1 is a member of the receptor tyrosine kinase (RTK) family, playing a pivotal role in regulating cell proliferation, survival, migration, and angiogenesis. This antibody specifically binds to the extracellular domain of FGFR1, competitively blocking FGF ligand binding and subsequently inhibiting receptor autophosphorylation and the activation of downstream signaling pathways such as MAPK/ERK and PI3K/Akt. This mechanism effectively suppresses tumor growth and pathological hyperplasia driven by aberrant FGFR1 signaling, making it a valuable tool in research on solid tumors and the development of targeted cancer therapies.

Anti-FGFR1/CD331 Antibody

Anti-FGFR1/CD331 Antibody

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Catalog No. T9901A-1357
Anti-FGFR1/CD331 Antibody is a humanized monoclonal antibody targeting fibroblast growth factor receptor 1 (FGFR1/CD331). FGFR1 is a member of the receptor tyrosine kinase (RTK) family, playing a pivotal role in regulating cell proliferation, survival, migration, and angiogenesis. This antibody specifically binds to the extracellular domain of FGFR1, competitively blocking FGF ligand binding and subsequently inhibiting receptor autophosphorylation and the activation of downstream signaling pathways such as MAPK/ERK and PI3K/Akt. This mechanism effectively suppresses tumor growth and pathological hyperplasia driven by aberrant FGFR1 signaling, making it a valuable tool in research on solid tumors and the development of targeted cancer therapies.
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Product Introduction

Bioactivity
Description
Anti-FGFR1/CD331 Antibody is a humanized monoclonal antibody targeting fibroblast growth factor receptor 1 (FGFR1/CD331). FGFR1 is a member of the receptor tyrosine kinase (RTK) family, playing a pivotal role in regulating cell proliferation, survival, migration, and angiogenesis. This antibody specifically binds to the extracellular domain of FGFR1, competitively blocking FGF ligand binding and subsequently inhibiting receptor autophosphorylation and the activation of downstream signaling pathways such as MAPK/ERK and PI3K/Akt. This mechanism effectively suppresses tumor growth and pathological hyperplasia driven by aberrant FGFR1 signaling, making it a valuable tool in research on solid tumors and the development of targeted cancer therapies.
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetFGFR1/CD331
Chemical Properties
Antibody Information
IsotypeIgG1
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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