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Anti-NPC2 Monoclonal Antibody
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Catalog No. TMAZ-0065
Alias NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Human epididymis-specific protein 1, Epididymal secretory protein E1
Anti-NPC2 Monoclonal Antibody is a humanized rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody can be used in ELISA,FCM.
Anti-NPC2 Monoclonal Antibody
Anti-NPC2 Monoclonal Antibody
😃Good
Catalog No. TMAZ-0065Alias NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Human epididymis-specific protein 1, Epididymal secretory protein E1
Anti-NPC2 Monoclonal Antibody is a humanized rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody can be used in ELISA,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μg | $196 | 12 days | 12 days | |
| 50 μg | $236 | 12 days | 12 days | |
| 100 μg | $330 | 12 days | 12 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-NPC2 Monoclonal Antibody is a humanized rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody can be used in ELISA,FCM. |
| Synonyms | NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Human epididymis-specific protein 1, Epididymal secretory protein E1 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of NPC2 overexpressed 476F cells with TMAZ-0065, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of NPC2 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed: 11125141, PubMed: 15937921, PubMed: 17018531, PubMed: 18772377, PubMed: 29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed: 17018531, PubMed: 18772377, PubMed: 27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed: 18823126). NPC2 binds cholesterol with a 1: 1 stoichiometry (PubMed: 17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed: 17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity) |
| Conjucates | Unconjugated |
| Others Formats | Biotin |
| Antibody Types Available | 2 |
| Immunogen | NPC2 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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