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Filaminast

Name: Filaminast
Brand: TargetMol
SKU: T31792
Price: 167 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31792Cas No. 141184-34-1

Alias Way-pda-641, WAY-PDA 641, UNII-CDD69JC61J, CDD69JC61J

Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.

Filaminast

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Purity: 99.99%

Catalog No. T31792Alias Way-pda-641, WAY-PDA 641, UNII-CDD69JC61J, CDD69JC61JCas No. 141184-34-1

Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$167	In Stock	In Stock
5 mg	$407	In Stock	In Stock
10 mg	$541	In Stock	In Stock
25 mg	$819	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock
100 mg	$1,470	In Stock	In Stock
200 mg	$1,990	-	In Stock
1 mL x 10 mM (in DMSO)	$369	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA HPLC HRMS HNMR

Product Introduction

Filaminast AI Summary

Filaminast inhibits the human MAPK p38alpha with an IC50 value of 960.0 nM. It also inhibits the human PDE4D catalytic domain with an IC50 of 1000.0 nM and the human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells with an IC50 value of 960.0 nM. These evaluations were performed using [3H]-cAMP or [3H]-cGMP as substrates and measured by the scintillation counting method after a 30-minute incubation period..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.
Synonyms	Way-pda-641, WAY-PDA 641, UNII-CDD69JC61J, CDD69JC61J

Chemical Properties

Molecular Weight	292.33
Formula	C₁₅H₂₀N₂O₄
Cas No.	141184-34-1
Smiles	O(C1=C(OC)C=CC(\C(=N\OC(N)=O)\C)=C1)C2CCCC2
Relative Density.	1.25g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32.5 mg/mL (111.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4208 mL	17.1040 mL	34.2079 mL	171.0396 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL	34.2079 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL	17.1040 mL
20 mM	0.1710 mL	0.8552 mL	1.7104 mL	8.5520 mL
50 mM	0.0684 mL	0.3421 mL	0.6842 mL	3.4208 mL
100 mM	0.0342 mL	0.1710 mL	0.3421 mL	1.7104 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc