Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-Phospho-PIN1(Ser71) Polyclonal Antibody
😃Good
Catalog No. TMAB-11143
Anti-Phospho-PIN1(Ser71) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PIN1(Ser71). Anti-Phospho-PIN1(Ser71) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PIN1(Ser71) Polyclonal Antibody
Anti-Phospho-PIN1(Ser71) Polyclonal Antibody
😃Good
Catalog No. TMAB-11143
Anti-Phospho-PIN1(Ser71) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PIN1(Ser71). Anti-Phospho-PIN1(Ser71) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PIN1(Ser71) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PIN1(Ser71). Anti-Phospho-PIN1(Ser71) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Nucleus speckle. Cytoplasm. |
| Tissue Specificity | The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human Pin1 around the phosphorylation site of Ser71 |
| Antigen Species | Human |
| Gene Name | PIN1 |
| Gene ID | |
| Protein Name | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
| Uniprot ID | |
| Function | Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. |
| Molecular Weight | Theoretical: 18 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-Phospho-PIN1(Ser71) Polyclonal Antibody | purchase Anti-Phospho-PIN1(Ser71) Polyclonal Antibody | Anti-Phospho-PIN1(Ser71) Polyclonal Antibody cost | order Anti-Phospho-PIN1(Ser71) Polyclonal Antibody | Anti-Phospho-PIN1(Ser71) Polyclonal Antibody molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.