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Anti-Phospho-MAPT (Ser324) Antibody (3R900) is an antibody targeting Phospho-MAPT (Ser324). Anti-Phospho-MAPT (Ser324) Antibody (3R900) can be used in ELISA, IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $208 | 7-10 days | |
100 μL | $348 | 7-10 days |
Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IF Reactivity: Human |
Alias | TAU and MAPT, p-MAPT (Ser324), p-MAPT (S324), Phospho-MAPT (S324), Paired helical filament-tau, Neurofibrillary tangle protein, MTBT1, Microtubule-associated protein tau, MAPTL, MAPT (p-Ser324), MAPT (p-S324) |
Ig Type | Rabbit IgG |
Clone | 3R900 |
Reactivity | Human |
Verified Activity | Immunofluorescence staining of SH-SY5Y cells with TMAH-00923 at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
Application | ELISA, IF |
Recommended Dose | IF:1:20-1:200. |
Antibody Type | Monoclonal |
Subcellular Localization | Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Secreted. |
Construction | Recombinant Antibody |
Purification | Affinity-chromatography |
Appearance | Liquid |
Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Research Background | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
Conjucates | Unconjugated |
Immunogen | A synthetic peptide: Human Phospho-MAPT (S324) |
Antigen Species | Human |
Gene ID | 4137 |
Uniprot ID | |
Biology Area | Neuroscience |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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