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Firocoxib

Name: Firocoxib
Brand: TargetMol
SKU: T7596
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7596Cas No. 189954-96-9

Alias ML 1785713

Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 0.13 μM, used for its anti-inflammatory properties in dogs and horses.

Firocoxib

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Purity: 99.84%

Catalog No. T7596Alias ML 1785713Cas No. 189954-96-9

Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 0.13 μM, used for its anti-inflammatory properties in dogs and horses.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$111	In Stock	In Stock
25 mg	$215	In Stock	In Stock
50 mg	$318	In Stock	In Stock
100 mg	$477	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Firocoxib AI Summary

Firocoxib exhibits potent inhibition of Prostaglandin G/H synthase 2 activity in human whole blood, with an IC50 value of 140.0 nM, while demonstrating weak inhibition against Prostaglandin G/H synthase 1, with an IC50 value greater than 100000.0 nM. It shows moderate activity in a U937 Microsome COX-1 assay, with an IC50 value of 25000.0 nM. In addition to its anti-inflammatory properties, Firocoxib has shown antiviral activities against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 μM after 48 hours, with an inhibition rate of 3.46%. Against the USA-WA1/2020 strain in HRCE cells, it yielded a hit score of 0.09893 at MOI 0.4 after 96 hours. The compound also inhibits SARS-CoV-2 3CL-Pro protease activity by 0.5656% at a 20μM concentration. However, high content imaging of virus-induced cytotoxicity in VERO-6 cells at 10 μM after 48 hours showed an inhibition of -0.04%. Additionally, Firocoxib exhibits inhibitory activity against human HDAC6, with inhibition percentages of -6.89% and -3.0% in enzymatic assays using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 0.13 μM, used for its anti-inflammatory properties in dogs and horses.
Targets&IC50	COX-2:0.13 μM, COX-1:7.5 μM
Synonyms	ML 1785713

Chemical Properties

Molecular Weight	336.4
Formula	C₁₇H₂₀O₅S
Cas No.	189954-96-9
Smiles	O(CC1CC1)C2=C(C(C)(C)OC2=O)C3=CC=C(S(C)(=O)=O)C=C3
Relative Density.	1.31 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 47 mg/mL (139.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9727 mL	14.8633 mL	29.7265 mL	148.6326 mL
5 mM	0.5945 mL	2.9727 mL	5.9453 mL	29.7265 mL
10 mM	0.2973 mL	1.4863 mL	2.9727 mL	14.8633 mL
20 mM	0.1486 mL	0.7432 mL	1.4863 mL	7.4316 mL
50 mM	0.0595 mL	0.2973 mL	0.5945 mL	2.9727 mL
100 mM	0.0297 mL	0.1486 mL	0.2973 mL	1.4863 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc