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Didemnin B

Name: Didemnin B
Brand: TargetMol
SKU: T25327
Price: 239 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25327Cas No. 77327-05-0

Alias NSC-325319, NSC325319, NSC 325319, Didemnin-B

Didemnin B (Didemnin-B) is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum that has antiviral and antitumor activity.

Didemnin B

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Purity: 98.4%

Catalog No. T25327Alias NSC-325319, NSC325319, NSC 325319, Didemnin-BCas No. 77327-05-0

Didemnin B (Didemnin-B) is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum that has antiviral and antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$239	-	In Stock
5 mg	$596	-	In Stock
10 mg	$818	-	In Stock
25 mg	$1,220	-	In Stock
50 mg	$1,650	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.4%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	Didemnin B (Didemnin-B) is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum that has antiviral and antitumor activity.
In vitro	Didemnin B is a potent inhibitor of L1210 growth in vitro[4].
In vivo	Didemnin B has activity against murine B16 melanoma, P388 leukemia, and M5076 sarcoma in vivo[4].
Synonyms	NSC-325319, NSC325319, NSC 325319, Didemnin-B

Chemical Properties

Molecular Weight	1112.35
Formula	C₅₇H₈₉N₇O₁₅
Cas No.	77327-05-0
Smiles	[H][C@@]12CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)C(=O)[C@@H](OC(=O)C[C@H](O)[C@]([H])(NC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)O)[C@@H](C)OC(=O)[C@H](Cc1ccc(OC)cc1)N(C)C2=O)[C@@H](C)CC)C(C)C
Relative Density.	1.0596 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (80.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8990 mL	4.4950 mL	8.9900 mL	44.9499 mL
5 mM	0.1798 mL	0.8990 mL	1.7980 mL	8.9900 mL
10 mM	0.0899 mL	0.4495 mL	0.8990 mL	4.4950 mL
20 mM	0.0449 mL	0.2247 mL	0.4495 mL	2.2475 mL
50 mM	0.0180 mL	0.0899 mL	0.1798 mL	0.8990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc