HVEM Protein, Human, Recombinant (Insect, hFc)

1. ED 50 < 0.1 μg/ml, measured by the neutralization assay using 929 cells in presence of 0.25 ng/ml of human TNF-beta, corresponding to a specific activity of > 1.0 × 10 4 units/mg.
2. Immobilized HVEM, hFc, Human at 2.0 μg/ml (100 µl/well) can bind biotinylated human BTLA.
3. Immobilized HVEM, hFc, Human at 2.0 μg/ml (100 µl/well) can bind biotinylated CD160, hFc, Human.

HVEM Protein, Human, Recombinant (Insect, hFc) is expressed in Baculovirus Insect Cells. The accession number is Q92956.

Human

Baculovirus Insect Cells

> 95% as determined by SDS-PAGE; > 95% as determined by HPLC

Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3 molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-γ and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA), which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.