Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774)

😃Good
Catalog No. TMAY-00150
Alias tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB

Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) is a Rabbit antibody targeting 4-1BB/CD137/TNFRSF9. Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) can be used in ELISA.

Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774)

Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774)

😃Good
Catalog No. TMAY-00150Alias tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB
Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) is a Rabbit antibody targeting 4-1BB/CD137/TNFRSF9. Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) can be used in ELISA.
Pack SizePriceAvailabilityQuantity
100 μL$199 7-10 days
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) is a Rabbit antibody targeting 4-1BB/CD137/TNFRSF9. Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) can be used in ELISA.
Aliastumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB
Ig Type
Monoclonal Rabbit IgG
Clone
3F774
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human 4-1BB/CD137 (rh 4-1BB/CD137; TMPY-01743; NP_001552.2; Met1-Gln186).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundCD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+and CD8+T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human 4-1BB/CD137 Protein (TMPY-01743)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

Sci Citations

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) | purchase Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) | Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774) cost | order Anti-4-1BB/CD137/TNFRSF9 Antibody (3F774)