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Licoflavone A

Name: Licoflavone A
Brand: TargetMol
SKU: TN1859
Price: 759 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1859Cas No. 61153-77-3

Licoflavone A is a natural product isolated from the roots of Glycyrrhiza uralensis.

Licoflavone A

🥰Excellent

Purity: 99.61%

Catalog No. TN1859Cas No. 61153-77-3

Licoflavone A is a natural product isolated from the roots of Glycyrrhiza uralensis.

Pack Size	Price	Availability
1 mg	$128	In Stock
5 mg	$277	In Stock
10 mg	$473	In Stock
25 mg	$759	In Stock
50 mg	Preferential	In Stock

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Batch Information

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Purity:99.61%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Licoflavone A is a natural product isolated from the roots of Glycyrrhiza uralensis.
Targets&IC50	PTP1B:54.5 μM
In vitro	Two new 2-arylbenzofurans, glycybenzofuran (1) and cyclolicocoumarone (2), together with 10 known flavonoids including licocoumarone (3), glycyrrhisoflavone (4), glisoflavone (5), cycloglycyrrhisoflavone (6), isoliquiritigenin (7), Licoflavone A (8), apigenin (9), isokaempferide (10), glycycoumarin (11), and isoglycycoumarin (12), were isolated from the roots of Glycyrrhiza uralensis and their structures were determined by extensive spectroscopic analyses. Compounds 1 and 5 showed significant protein tyrosine phosphatase-1B (PTP1B) inhibitory activity in vitro with the IC50 values of 25.5 and 27.9 μM, respectively.

Chemical Properties

Molecular Weight	322.35
Formula	C₂₀H₁₈O₄
Cas No.	61153-77-3
Smiles	CC(C)=CCc1cc2c(cc1O)oc(cc2=O)-c1ccc(O)cc1
Relative Density.	1.279 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 100 mg/mL (310.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1022 mL	15.5111 mL	31.0222 mL	155.1109 mL
5 mM	0.6204 mL	3.1022 mL	6.2044 mL	31.0222 mL
10 mM	0.3102 mL	1.5511 mL	3.1022 mL	15.5111 mL
20 mM	0.1551 mL	0.7756 mL	1.5511 mL	7.7555 mL
50 mM	0.0620 mL	0.3102 mL	0.6204 mL	3.1022 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5511 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc