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Duvelisib

🥰Excellent
Catalog No. T1988Cas No. 1201438-56-3
Alias IPI-145, INK1197

Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ, with effects on p110δ (IC50 value is 0.0025 μM), p110γ (IC50 value is 0.274 μM), p110β (IC50 value is 0.85 μM) and p110α (IC50 value is 1.602 μM).

Duvelisib

Duvelisib

🥰Excellent
Purity: 99.74%
Catalog No. T1988Alias IPI-145, INK1197Cas No. 1201438-56-3
Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ, with effects on p110δ (IC50 value is 0.0025 μM), p110γ (IC50 value is 0.274 μM), p110β (IC50 value is 0.85 μM) and p110α (IC50 value is 1.602 μM).
Pack SizePriceAvailabilityQuantity
2 mg$40In Stock
5 mg$61In Stock
10 mg$85In Stock
50 mg$158In Stock
100 mg$256In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.74%
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Product Introduction

Bioactivity
Description
Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ, with effects on p110δ (IC50 value is 0.0025 μM), p110γ (IC50 value is 0.274 μM), p110β (IC50 value is 0.85 μM) and p110α (IC50 value is 1.602 μM).
Targets&IC50
p110δ:2.5 nM, p110α:1602 nM, p110β:85 nM, PI3Kγ:243 pM(Ki), PI3Kβ:1564 pM(Ki), PI3Kδ:23 pM(Ki), p110γ:27.4 nM
In vitro
METHODS: Primary AML blasts (AML#2 and AML#5) were treated with Duvelisib (INK1197, IPI-145) (0.1, 0.5, 1 μM) and cultured for 4 hours. They were then incubated with BMSC conditioned medium for 5 minutes. Whole cell extracts were prepared and Western blot analysis was performed for pAKT (s473 and t308) and total AKT, as well as pMAPK and total MAPK.
RESULTS Duvelisib (INK1197, IPI-145) inhibited BMSC CM-induced pAKT (s473 and t308) activation at 0.1 μM; Duvelisib (INK1197, IPI-145) blocked blast migration through its inhibitory effect on AKT phosphorylation at the t308 site. [1]
In vivo
METHODS: We used an Eμ-TCL1 adoptive transfer mouse model of CLL. After Duvelisib (INK1197, IPI-145) (100 mg/kg, once daily, oral, for 21 days),
RESULTS Duvelisib (INK1197, IPI-145) significantly reduced the CLL burden (CD19 CD5 B cells) in the peripheral blood of mice; at the same time, the total number of CD3 T cells in the mice was also lower, but the CD4/CD8 ratio was also reduced. [2]
AliasIPI-145, INK1197
Chemical Properties
Molecular Weight416.86
FormulaC22H17ClN6O
Cas No.1201438-56-3
SmilesC[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Relative Density.1.474 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: < 1 mg/mL (insoluble or slightly soluble)

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