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2614W94

Name: 2614W94
Brand: TargetMol
SKU: T10089
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10089Cas No. 205187-35-5

2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.

2614W94

🥰Excellent

Purity: 99.6%

Catalog No. T10089Cas No. 205187-35-5

2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$78	In Stock	In Stock
5 mg	$179	In Stock	In Stock
10 mg	$260	In Stock	In Stock
25 mg	$407	In Stock	In Stock
50 mg	$547	In Stock	In Stock
100 mg	$708	In Stock	In Stock
200 mg	$958	-	In Stock
1 mL x 10 mM (in DMSO)	$201	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.6%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.
Targets&IC50	MAO:(ki)1.6 nM , MAO:5 nM
In vitro	2614W94 (30 nM) shows no inhibition of MAO-B[1].
In vivo	In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg[1].

Chemical Properties

Molecular Weight	344.31
Formula	C₁₅H₁₁F₃O₄S
Cas No.	205187-35-5
Smiles	O=S1(=O)C=2C(OC=3C1=CC=CC3)=CC(OC(C(F)(F)F)C)=CC2
Relative Density.	1.449 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (130.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9044 mL	14.5218 mL	29.0436 mL	145.2180 mL
5 mM	0.5809 mL	2.9044 mL	5.8087 mL	29.0436 mL
10 mM	0.2904 mL	1.4522 mL	2.9044 mL	14.5218 mL
20 mM	0.1452 mL	0.7261 mL	1.4522 mL	7.2609 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	2.9044 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4522 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc