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2614W94

Name: 2614W94
Brand: TargetMol
SKU: T10089
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10089Cas No. 205187-35-5

2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.

2614W94

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Purity: 99.6%

Catalog No. T10089Cas No. 205187-35-5

2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$78	In Stock	In Stock
5 mg	$179	In Stock	In Stock
10 mg	$260	In Stock	In Stock
25 mg	$407	In Stock	In Stock
50 mg	$547	In Stock	In Stock
100 mg	$708	In Stock	In Stock
200 mg	$958	-	In Stock
1 mL x 10 mM (in DMSO)	$201	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.
Targets&IC50	MAO:5 nM , MAO:(ki)1.6 nM
In vitro	2614W94 (30 nM) shows no inhibition of MAO-B[1].
In vivo	In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg[1].

Chemical Properties

Molecular Weight	344.31
Formula	C₁₅H₁₁F₃O₄S
Cas No.	205187-35-5
Smiles	O=S1(=O)C=2C(OC=3C1=CC=CC3)=CC(OC(C(F)(F)F)C)=CC2
Relative Density.	1.449 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (130.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9044 mL	14.5218 mL	29.0436 mL	145.2180 mL
5 mM	0.5809 mL	2.9044 mL	5.8087 mL	29.0436 mL
10 mM	0.2904 mL	1.4522 mL	2.9044 mL	14.5218 mL
20 mM	0.1452 mL	0.7261 mL	1.4522 mL	7.2609 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	2.9044 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4522 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc