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Guanosine 5'-diphosphate sodium

Name: Guanosine 5'-diphosphate sodium
Brand: TargetMol
SKU: T72120
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72120 Copy Product Info

Purity: 99.98%

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Guanosine 5'-diphosphate sodium is a nucleoside diphosphate involved in various intracellular signaling processes, particularly in G protein–coupled receptor signaling, where it regulates G protein activation through GDP/GTP exchange. It may also indirectly influence ion channel activity, such as ATP-sensitive potassium channels.

Cas No. 43139-22-6

Pack Size	Price	USA Stock	Global Stock
5 mg	$30	-	In Stock
10 mg	$48	-	In Stock
25 mg	$64	-	In Stock
50 mg	$81	-	In Stock
100 mg	$106	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Guanosine 5'-diphosphate sodium is a nucleoside diphosphate involved in various intracellular signaling processes, particularly in G protein–coupled receptor signaling, where it regulates G protein activation through GDP/GTP exchange. It may also indirectly influence ion channel activity, such as ATP-sensitive potassium channels.
In vitro	Guanosine 5'-diphosphate sodium (100 μM–1 mM) sodium, 96% (HPLC) activates ATP-sensitive potassium channels in rabbit portal veins in the presence of Pinacidil [1]. Guanosine 5'-diphosphate sodium (10 μM, 24 hours) sodium, 96% (HPLC) inhibits ferritin-induced FPN internalization in the FPN-GFP cell line (HEK293T) and antagonizes ferritin to increase FPN-mediated cellular iron efflux in HepG2 and Caco-2 cells [2].
In vivo	Guanosine 5'-diphosphate sodium (30 mg/kg, intraperitoneal injection, single dose) sodium, 96% (HPLC), when used in combination with the iron supplement FeSO₄ (2 mg/kg), increases iron absorption in normal BALB/c mice [2]. Guanosine 5'-diphosphate sodium (30 mg/kg, intraperitoneal injection, once every 24 hours for 2 weeks) sodium, 96% (HPLC), when used in combination with FeSO₄ (2 mg/kg), improves iron malabsorption in turpentine-induced mice [2].

Chemical Properties

Molecular Weight	465.18
Formula	C₁₀H₁₄N₅NaO₁₁P₂
Cas No.	43139-22-6
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP([O-])(O)=O)(O)=O)N2C3=C(C(N=C(N3)N)=O)N=C2.[Na+]

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (171.98 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1497 mL	10.7485 mL	21.4971 mL	107.4853 mL
5 mM	0.4299 mL	2.1497 mL	4.2994 mL	21.4971 mL
10 mM	0.2150 mL	1.0749 mL	2.1497 mL	10.7485 mL
20 mM	0.1075 mL	0.5374 mL	1.0749 mL	5.3743 mL
50 mM	0.0430 mL	0.2150 mL	0.4299 mL	2.1497 mL
100 mM	0.0215 mL	0.1075 mL	0.2150 mL	1.0749 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

GDP sodium

Related Tags: Guanosine 5'-diphosphate sodium chemical structure | Guanosine 5'-diphosphate sodium in vivo | Guanosine 5'-diphosphate sodium in vitro | Guanosine 5'-diphosphate sodium formula | Guanosine 5'-diphosphate sodium molecular weight