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LTR

LTR retrotransposons are class I transposable element characterized by the presence of Long Terminal Repeats (LTRs) directly flanking an internal coding region. As retrotransposons, they mobilize through reverse-transcription of their mRNA and integration of the newly created cDNA into another location. Their mechanism of retrotransposition is shared with retroviruses, with the difference that most LTR-retrotransposons do not form infectious particles that leave the cells and therefore only replicate inside their genome of origin.

  • Montelukast sodium
    T1677L151767-02-1
    Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
    • $41
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  • hnps-PLA Inhibitor
    T4192185298-58-2
    Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).
    • $51
    In Stock
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  • Darbufelone
    T10960139226-28-1In house
    Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.
    • $37
    In Stock
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  • LTB4-IN-1
    T10917133012-00-7In house
    LTB4-IN-1 (Anti-inflammatory agent 2) with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4).
    • $291
    In Stock
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  • FPL 55712
    T2278740785-97-5In house
    FPL 55712 is a leukotriene receptor and SRS-A antagonist that inhibits bronchoconstriction and can be used in studies of asthma and coronary artery thrombosis.
    • $86 TargetMol
    In Stock
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  • Linetastine
    T25737159776-68-8In house
    Linetastine (TMK-688) is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of asthma, atherosclerosis, and peptic ulcers.
    • $130
    In Stock
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  • BIRM 271
    T77638149106-77-4In house
    BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leukotriene B4 with IC50 of 40 nM.
    • $195
    In Stock
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    TargetMol | Inhibitor Sale
  • Croconazole
    T987877175-51-0In house
    Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and
    • $52
    In Stock
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  • Ticolubant
    T28974154413-61-3In house
    Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.
    • $210
    In Stock
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  • MCI826
    T16026140646-80-6
    MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model of advanced asthma.
    • $700
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  • Moxilubant HCl
    T68108L146957-32-6
    Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid arthritis.
    • $195
    In Stock
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  • YM 16638
    T35258104073-72-5In house
    YM 16638 is an orally active leukotriene (LT) antagonist with triglyceride-lowering and peroxisome-increasing effects that can be used to study antigen-induced early and late airway responses in allergic sheep.
    • $397 TargetMol
    In Stock
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  • Veliflapon
    T13295128253-31-6In house
    Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.
    • $766
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  • LTβR-IN-1
    T118862189366-77-4In house
    LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation of p65 mediated by TNF-α receptor, but inhibits the nuclear translocation of p52 stimulated by TWEAK or Anti-LTβR. Translocation with IC50 of 10 μM. LTβR-IN-1 regulates the NF-kB signaling pathway through a ligand-independent manner.
    • $30
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  • Montelukast
    T1677158966-92-8
    Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
    • $29
    In Stock
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    TargetMol | Citations Cited
  • Diffractaic Acid
    T4114436-32-8
    Diffractaic Acid (NSC 685595) can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
    • $1,130
    35 days
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    TargetMol | Citations Cited
  • MK-571 sodium
    T3148115103-85-0
    MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
    • $47
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    TargetMol | Citations Cited
  • Bestatin
    T125758970-76-6
    Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage, and bone marrow stem cell as well as stimulates the release of interleukin-1 and -2, thus further enhances its antitumor activity.
    • $48
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    TargetMol | Citations Cited
  • MK 571
    T7841115104-28-4
    MK 571 (L660711) is an orally active antagonist of CysLT1 receptor.
    • $38
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    TargetMol | Citations Cited
  • Pranlukast
    T0694103177-37-3
    Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
    • $50
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    TargetMol | Citations Cited
  • 3-(4-Hydroxyphenyl)-1-propanol
    T373810210-17-0
    3-(4-hydroxyphenyl)-1-propanol is a member of the class of compounds known as 1-hydroxy-2-unsubstituted benzenoids.
    • $41
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  • DW-1350
    T15182491577-61-8
    DW-1350 is an antagonist of LTB4 receptor.
    • $1,520
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  • Darbufelone mesylate
    T10960L139340-56-0
    Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 value of 20 μM.
    • $122
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  • Acebilustat
    T3715943764-99-6
    Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
    • $38
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  • Amelubant
    T14210346735-24-8
    Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM
      7-10 days
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    • Ergosta-7,22-dien-3-one
      TN398332507-77-0
      Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory properties, it stimulates nitric oxide production, induces gene expression, and induces the production of TLRs, cytokines, chemokines, and cellular adhesion molecules.
      • $1,168
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    • CP-105696
      T15002158081-99-3
      CP-105696 is a potent and selective leukotriene B4 (LTB4) receptor antagonist for the study of allograft rejection.
      • $128
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    • Etalocib
      T22358161172-51-6
      Etalocib (LY293111) is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-lipoxygenase. It has antineoplastic activities.
      • $108
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    • LY309887
      T15813127228-54-0
      LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
      • $1,400
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    • Moxilubant
      T68108146978-48-5
      Moxilubant is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid arthritis.
      • $112
      Backorder
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      QTY
    • γ-Linolenic Acid methyl ester
      T2150416326-32-2
      γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.
      • $29
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    • Bunaprolast
      T1719199107-52-5
      Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase and TXB2 release.
      • $700
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    • trans-Hinokiresinol
      TN516417676-24-3
      Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen
      • $159
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    • Tebufelone
      T68155112018-00-5
      Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticulitis properties in various animal models. Tebufelone potently inhibits the formation of prostaglandins (PGE2) and blocks the formation of lipoxygenase pathway products [leukotriene (LTB4)] in rat macrophages (IC50 = 20 microM) and human whole blood (IC50 = 22 microM) in vitro. = 20 microM) and human whole blood (IC50 = 22 microM) from the formation of lipoxygenase pathway products [leukotriene (LTB4)] in vitro.
      • $52
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    • Fiboflapon sodium
      T11487L1196070-26-4
      Fiboflapon sodium (GSK2190915) is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood.
      • $89
      5 days
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    • Ontazolast
      T68119147432-77-7
      Ontazolast is a small molecule leukotriene B4 receptor (LTB4R) antagonist for the treatment of immune system disorders and respiratory diseases.Ontazolast is a candidate compound for the treatment of asthma.
      • $85
      In Stock
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