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Dihydroevocarpine
🥰Excellent
Catalog No. TN1099Cas No. 15266-35-0
Alias 1-methyl-2-tridecylquinolin-4-one
Dihydroevocarpine (1-methyl-2-tridecylquinolin-4-one) induces AML cytotoxicity, apoptosis and G0/G1 blockade, and inhibits tumor growth by inhibiting mTORC1/2 activity and the mTOR pathway in an acute myeloid leukemia (AML) xenograft model.
Dihydroevocarpine
🥰Excellent
Purity: 98.25%
Catalog No. TN1099Alias 1-methyl-2-tridecylquinolin-4-oneCas No. 15266-35-0
Dihydroevocarpine (1-methyl-2-tridecylquinolin-4-one) induces AML cytotoxicity, apoptosis and G0/G1 blockade, and inhibits tumor growth by inhibiting mTORC1/2 activity and the mTOR pathway in an acute myeloid leukemia (AML) xenograft model.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $54 | In Stock | |
| 5 mg | $129 | In Stock | |
| 10 mg | $198 | In Stock | |
| 25 mg | $320 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $142 | In Stock |
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Purity:98.25%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dihydroevocarpine (1-methyl-2-tridecylquinolin-4-one) induces AML cytotoxicity, apoptosis and G0/G1 blockade, and inhibits tumor growth by inhibiting mTORC1/2 activity and the mTOR pathway in an acute myeloid leukemia (AML) xenograft model. |
| Targets&IC50 | CCRF-CEM cells:14.08 μM, CEM/ADR5000 cells:33.14 μM |
| In vitro | Dihydroevocarpine exhibits moderate in vitro cytotoxicity against CCRF-CEM and CEM/ADR5000 leukemia cell lines, with IC₅₀ values of 14.08 μM and 33.14 μM, respectively. [1] |
| In vivo | BALB/C nude mice bearing subcutaneous HL-60 leukemia cells were treated with intraperitoneal injections of Dihydroevocarpine (10 mg/kg/day) for 20 days, resulting in a significant antitumor effect.[2] |
| Alias | 1-methyl-2-tridecylquinolin-4-one |
| Molecular Weight | 341.53 |
| Formula | C23H35NO |
| Cas No. | 15266-35-0 |
| Smiles | O=C1C=C(N(C=2C=CC=CC12)C)CCCCCCCCCCCCC |
| Relative Density. | 0.964 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (35.14 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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