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MC1742

Name: MC1742
Brand: TargetMol
SKU: T35762
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35762Cas No. 1776116-74-5

Alias MC 1742

MC1742 is a broad-spectrum HDAC inhibitor, inhibiting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, and HDAC11. MC1742 inhibits the growth of parasites in vitro, blocking the growth of Toxoplasma gondii tachyzoites and severely disrupting the expression of parasitic genes. MC1742 has potential anticancer activity, inhibiting the growth arrest, apoptosis, and growth of cancer cells. MC1742 has potential anticancer activity, inhibiting growth arrest, apoptosis and differentiation of cancer cells.

MC1742

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Purity: 99.20%

Catalog No. T35762Alias MC 1742Cas No. 1776116-74-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.20%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	MC1742 is a broad-spectrum HDAC inhibitor, inhibiting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, and HDAC11. MC1742 inhibits the growth of parasites in vitro, blocking the growth of Toxoplasma gondii tachyzoites and severely disrupting the expression of parasitic genes. MC1742 has potential anticancer activity, inhibiting the growth arrest, apoptosis, and growth of cancer cells. MC1742 has potential anticancer activity, inhibiting growth arrest, apoptosis and differentiation of cancer cells.
Targets&IC50	HDAC2:0.11 μM, HDAC1:0.1 μM, HDAC11:0.1 μM, HDAC3:0.02 μM, HDAC10:0.04 μM, HDAC6:0.007 μM, HDAC8:0.61 μM
In vitro	MC1742 is a potent HDAC inhibitor with IC50 values of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM, and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, and HDAC11, respectively.MC1742 was able to increase the levels of acetylated-H3 and acetylated microtubule proteins and inhibit the proliferation of cancer stem cells. MC1742 (0.5 and 2 μM; 24 h) was able to enhance acetylation levels in a dose-dependent manner, as evidenced by patchy nuclear staining of acetylated histone H3. MC1742 (0.5, 1 and 2 μM; 24, 48 and 72 h) significantly induced apoptosis in all cancer stem cell cultures. MC1742 (0.025-0.5 μM; 14 days) was able to significantly promote bone vesicle formation with a dose-dependent effect. [1]
Synonyms	MC 1742

Chemical Properties

Molecular Weight	395.48
Formula	C₂₁H₂₁N₃O₃S
Cas No.	1776116-74-5
Smiles	O=C1N=C(SCCCCC(=O)NO)NC(=C1)C=2C=CC(=CC2)C=3C=CC=CC3
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (404.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5286 mL	12.6429 mL	25.2857 mL	126.4286 mL
5 mM	0.5057 mL	2.5286 mL	5.0571 mL	25.2857 mL
10 mM	0.2529 mL	1.2643 mL	2.5286 mL	12.6429 mL
20 mM	0.1264 mL	0.6321 mL	1.2643 mL	6.3214 mL
50 mM	0.0506 mL	0.2529 mL	0.5057 mL	2.5286 mL
100 mM	0.0253 mL	0.1264 mL	0.2529 mL	1.2643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc