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Atipamezole

Name: Atipamezole
Brand: TargetMol
SKU: T6766
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6766Cas No. 104054-27-5

Alias MPV 1248, Antisedan

Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.

Atipamezole

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Purity: 99.88%

Catalog No. T6766Alias MPV 1248, AntisedanCas No. 104054-27-5

Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$252	In Stock	In Stock
100 mg	$378	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
Targets&IC50	α2-adrenoceptor antagonist:1.6 nM（Ki）
In vitro	The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].
In vivo	Atipamezole is well-tolerated in rodents and exhibits modest cardiovascular effects (0.01–1 mg/kg, i.v.) in anesthetized, normotensive rats. It is frequently used by veterinarians to reverse sedation or anesthesia in animals. Atipamezole enhances sexual activity in rats and monkeys and increases pain-related responses in animals with sustained nociception by blocking noradrenergic feedback inhibition of pain. At low doses, it improves alertness, selective attention, planning, learning, and recall in experimental animals, although not necessarily affecting short-term working memory[1].
Synonyms	MPV 1248, Antisedan

Chemical Properties

Molecular Weight	212.29
Formula	C₁₄H₁₆N₂
Cas No.	104054-27-5
Smiles	C(C)C1(CC=2C(C1)=CC=CC2)C3=CN=CN3
Relative Density.	1.115 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 39 mg/mL (183.71 mM), Sonication is recommended.

Ethanol: 39 mg/mL (183.71 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.7105 mL	23.5527 mL	47.1054 mL	235.5269 mL
5 mM	0.9421 mL	4.7105 mL	9.4211 mL	47.1054 mL
10 mM	0.4711 mL	2.3553 mL	4.7105 mL	23.5527 mL
20 mM	0.2355 mL	1.1776 mL	2.3553 mL	11.7763 mL
50 mM	0.0942 mL	0.4711 mL	0.9421 mL	4.7105 mL
100 mM	0.0471 mL	0.2355 mL	0.4711 mL	2.3553 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc