Shopping Cart

Your shopping cart is currently empty

PK150

Name: PK150
Brand: TargetMol
SKU: T7897
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T7897Cas No. 2165324-62-7

PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations.

PK150

Copy Product Info

😃Good

Purity: 99.54%

Catalog No. T7897Cas No. 2165324-62-7

PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$146	In Stock	In Stock
50 mg	$233	In Stock	-
100 mg	$375	In Stock	-
200 mg	$552	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.54%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PK150 AI Summary

PK150 exhibits notable antibacterial activity against a range of bacterial strains including Staphylococcus aureus, vancomycin-resistant Enterococcus, and Mycobacterium tuberculosis. It effectively reduces microbial growth with Minimum Inhibitory Concentration (MIC) values of 0.18 ug/mL for Staphylococcus aureus, 1.0 ug/mL for vancomycin-resistant Enterococcus, and 0.93 ug/mL for Mycobacterium tuberculosis. Specifically against methicillin-resistant Staphylococcus aureus, it shows an MIC of 0.12 ug/mL and 300.0 nM measured after 24 hours. The compound also demonstrates efficacy against methicillin-sensitive Staphylococcus epidermidis and exhibits cytotoxicity against human HeLa and HepG2 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations.
Targets&IC50	MRSA:0.3-1 µM (MIC), MSSA:0.3 µM (MIC), VISA:0.3 µM (MIC)

Chemical Properties

Molecular Weight	394.68
Formula	C₁₅H₈ClF₅N₂O₃
Cas No.	2165324-62-7
Smiles	FC(F)(F)c1cc(NC(=O)Nc2ccc3OC(F)(F)Oc3c2)ccc1Cl
Relative Density.	1.63 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (633.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5337 mL	12.6685 mL	25.3370 mL	126.6849 mL
5 mM	0.5067 mL	2.5337 mL	5.0674 mL	25.3370 mL
10 mM	0.2534 mL	1.2668 mL	2.5337 mL	12.6685 mL
20 mM	0.1267 mL	0.6334 mL	1.2668 mL	6.3342 mL
50 mM	0.0507 mL	0.2534 mL	0.5067 mL	2.5337 mL
100 mM	0.0253 mL	0.1267 mL	0.2534 mL	1.2668 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc