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Anti-SUZ12 Antibody (4D889)

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Catalog No. TMAB-13290

Anti-SUZ12 Antibody (4D889) is a Rabbit antibody targeting SUZ12. Anti-SUZ12 Antibody (4D889) can be used in WB.

Anti-SUZ12 Antibody (4D889)

Anti-SUZ12 Antibody (4D889)

😃Good
Catalog No. TMAB-13290
Anti-SUZ12 Antibody (4D889) is a Rabbit antibody targeting SUZ12. Anti-SUZ12 Antibody (4D889) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2637-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-SUZ12 Antibody (4D889) is a Rabbit antibody targeting SUZ12. Anti-SUZ12 Antibody (4D889) can be used in WB.
Ig Type
IgG
Clone
4D889
Reactivity
Human,Mouse,Rat
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityOverexpressed in breast and colon cancer.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundUZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. SUZ12 is a component of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3. SUZ12 is a component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like BMI1, CBX4, CBX8, PHC2, PHC3, SCMH1, RING1 and RNF2. SUZ12 mRNA is upregulated in a number of tumors including breast and colon.
Antigen Details
Immunogen
A synthesized peptide: human SUZ12
Antigen Species
Human
Gene Name
SUZ12
Gene ID
23512
Protein Name
Polycomb protein SUZ12
Uniprot ID
Q15022
Function
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Chemical Properties
Molecular WeightTheoretical: 83 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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