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Anti-SUZ12 Antibody (4D889)
Catalog No. TMAB-13290 Copy Product Info
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Anti-SUZ12 Antibody (4D889) is a Rabbit antibody targeting SUZ12. Anti-SUZ12 Antibody (4D889) can be used in WB.
Anti-SUZ12 Antibody (4D889)
Copy Product Info🥰Excellent
Catalog No. TMAB-13290
Anti-SUZ12 Antibody (4D889) is a Rabbit antibody targeting SUZ12. Anti-SUZ12 Antibody (4D889) can be used in WB.
Anti-SUZ12 Antibody
(4D889)
(4D889)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-SUZ12 Antibody (4D889) is a Rabbit antibody targeting SUZ12. Anti-SUZ12 Antibody (4D889) can be used in WB. |
| Ig Type | IgG |
| Clone | 4D889 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with SUZ12 monoclonal antibody, unconjugated (TMAB-13290) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Overexpressed in breast and colon cancer. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | UZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. SUZ12 is a component of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3. SUZ12 is a component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like BMI1, CBX4, CBX8, PHC2, PHC3, SCMH1, RING1 and RNF2. SUZ12 mRNA is upregulated in a number of tumors including breast and colon. |
| Immunogen | A synthesized peptide: human SUZ12 |
| Antigen Species | Human |
| Gene Name | SUZ12 |
| Gene ID | |
| Protein Name | Polycomb protein SUZ12 |
| Uniprot ID | |
| Function | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Molecular Weight | Theoretical: 83 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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