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2-Di-1-ASP

Name: 2-Di-1-ASP
Brand: TargetMol
SKU: T18883
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18883Cas No. 2156-29-8

2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.

2-Di-1-ASP

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Purity: 99.98%

Catalog No. T18883Cas No. 2156-29-8

2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:Red

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.
In vitro	Compound 18a (2-Di-1-ASP) exhibits marked fluorescence intensification, achieving up to a 300-fold increase, specifically in the presence of G4 structures, while maintaining significant selectivity against double-stranded DNA. Moreover, 2-Di-1-ASP demonstrates fluorimetric selectivity for parallel forms of G4-DNA, including c-kit2, c-myc, and c-kit87up.
Cell Research	2-Di-1-ASP as an in situ mitochondrial stain Procedure 1. Cultivate cells to a suitable state, seed them on a 24 mm diameter coverslip at a pre-confluent density, add 3 μM 2-Di-1-ASP and incubate at 28°C for 40 minutes. 2. Rinse with Hank's balanced salt solution (HBSS) to remove extracellular 2-Di-1-ASP, and then observe mitochondrial activity under a microscope. The above information is based on published literature. Experimental procedures should be appropriately modified to meet specific research demands.

Chemical Properties

Molecular Weight	366.24
Formula	C₁₆H₁₉IN₂
Cas No.	2156-29-8
Smiles	[I-].CN(C)c1ccc(\C=C\c2cccc[n+]2C)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (54.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7304 mL	13.6522 mL	27.3045 mL	136.5225 mL
5 mM	0.5461 mL	2.7304 mL	5.4609 mL	27.3045 mL
10 mM	0.2730 mL	1.3652 mL	2.7304 mL	13.6522 mL
20 mM	0.1365 mL	0.6826 mL	1.3652 mL	6.8261 mL
50 mM	0.0546 mL	0.2730 mL	0.5461 mL	2.7304 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc