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PDM2

Name: PDM2
Brand: TargetMol
SKU: T4608
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4608Cas No. 688348-25-6

PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.

PDM2

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Purity: 99.44%

Catalog No. T4608Cas No. 688348-25-6

PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$47	In Stock	In Stock
50 mg	$76	In Stock	In Stock
100 mg	$137	In Stock	In Stock
200 mg	$198	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
Targets&IC50	AhR:1.2±0.4 nM(Ki)
In vitro	In a previous screening study, it was found that the replacement of resveratrol hydroxyls by the same substituent produced compounds with the following order of affinity: OH (resveratrol) , OMe < F < CF3 < Cl (PDM2). PDM2 exhibited a Ki of 1.25 for AhR and no affinity for ER, indicating that replacement of hydroxyl with chloride could abolish binding on ER and dramatically increase the affinity for AhR. Moreover, among its analogs PDM2 was the most potent AhR antagonists in this series, being 10-fold more efficient than resveratrol. PDM2, devoid of measurable affinity for ER, did not display any effect on ER-driven transcription. Therefore, PDM2 was considered as a selective AhR modulator with regard to ER. In addition, its trimethoxylated derivatives and 3,5-methoxy derivatives were able to induce cytotoxicity at doses lower than 100 nM, which was consistent with previous data. 3,5-Methoxy derivatives, however, only showed cytotoxicity at concentrations higher than 10 μM [1].

Chemical Properties

Molecular Weight	283.58
Formula	C₁₄H₉Cl₃
Cas No.	688348-25-6
Smiles	Clc1ccc(\C=C\c2cc(Cl)cc(Cl)c2)cc1
Relative Density.	1.360 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (176.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (8.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5263 mL	17.6317 mL	35.2634 mL	176.3171 mL
5 mM	0.7053 mL	3.5263 mL	7.0527 mL	35.2634 mL
10 mM	0.3526 mL	1.7632 mL	3.5263 mL	17.6317 mL
20 mM	0.1763 mL	0.8816 mL	1.7632 mL	8.8159 mL
50 mM	0.0705 mL	0.3526 mL	0.7053 mL	3.5263 mL
100 mM	0.0353 mL	0.1763 mL	0.3526 mL	1.7632 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc