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Vinburnine
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Catalog No. T2149Cas No. 4880-88-0
Alias Vincamone, L-Eburnamonine, Eburnalritardo, (-)-Vincamone, (-)-Eburnamonine
Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.
Vinburnine
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Purity: 99.83%
Catalog No. T2149Alias Vincamone, L-Eburnamonine, Eburnalritardo, (-)-Vincamone, (-)-EburnamonineCas No. 4880-88-0
Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $39 | In Stock | In Stock | |
| 50 mg | $55 | In Stock | In Stock | |
| 100 mg | $80 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.83%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Vinburnine AI Summary
Vinburnine exhibits a wide range of bioactivities encompassing antimalarial, anticancer, antiviral, and DNA replication-modulating properties. It demonstrates significant inhibition of the malarial parasite plastid, with potency values ranging from 2332.3 nM to 13115.4 nM, and it inhibits growth in various human tumor cell lines with GI50 values between 1309.18 nM and 100000.0 nM. The compound also induces DNA re-replication in normal breast cells and colon adenocarcinoma cells, and shows potency in inhibiting interactions related to Hepatitis C Virus, Vif-A3G interactions, GLP-1 Receptor, and ATXN expression.
In addition, Vinburnine inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence and absence of CPT and exhibits synthetic lethality in tumor cells as well as inhibition of Vaccinia Orthopoxvirus. The compound blocks the entry of Ebola Virus in various assays. It also shows significant activity as an acetylcholinesterase (AChE) inhibitor but exhibits much lower activity against horse butyrylcholinesterase (BChE).
Cytotoxicity assays reveal that Vinburnine has potent cytotoxic effects on various human cell lines, including KMS-12-BM, U266, RPMI8226, LNCAP, and MDA-MB-231 cells, with an IC50 value of 41800.0 nM against MDA-MB-231 cells after 96 hours. It also demonstrates high inhibition of sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells, suggesting potent inhibitory effects on these transporters.
Furthermore, Vinburnine shows antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentrations, with various degrees of efficacy. The compound also exhibits 9.522% inhibition of SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM and moderate inhibition of human HDAC6 in enzymatic assays.
Overall, Vinburnine is a multifunctional compound with potential applications in treating malaria, cancer, and viral infections, including SARS-CoV-2..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine. |
| Synonyms | Vincamone, L-Eburnamonine, Eburnalritardo, (-)-Vincamone, (-)-Eburnamonine |
| Molecular Weight | 294.39 |
| Formula | C19H22N2O |
| Cas No. | 4880-88-0 |
| Smiles | [H][C@]12N3CCC[C@@]1(CC)CC(=O)n1c2c(CC3)c2ccccc12 |
| Relative Density. | 1.34 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.95 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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