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F 14679

Catalog No. T62269   CAS 208109-38-0
Synonyms: F 13714

F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.

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F 14679 Chemical Structure
F 14679, CAS 208109-38-0
Pack Size Availability Price/USD Quantity
25 mg 10-14 weeks $ 1,330.00
50 mg 10-14 weeks $ 1,728.00
100 mg 10-14 weeks $ 2,595.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Purity: 99.09%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
Targets&IC50 5-HT1A receptor:10.23 (pKi), 5-HT1B receptor:5.12 (pIC50)
In vivo In the fear-potentiated startle test, F13714 (0.04-0.16 mg/kg) reduced the expression of cued and contextual fear response.[2]
Synonyms F 13714
Molecular Weight 422.9
Formula C21H25ClF2N4O
CAS No. 208109-38-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Pauwels PJ, et al. Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. J Pharmacol Exp Ther. 2003;307(2):608-614. 2. Zhao Y, et al. Activation of somatodendritic 5-HT1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test. Psychopharmacology (Berl). 2019;236(4):1171-1185.

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Keywords

F 14679 208109-38-0 GPCR/G Protein Neuroscience 5-HT Receptor F14679 F13714 F-13714 F 13714 F-14679 inhibitor inhibit

 

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