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Anti-NRSF Polyclonal Antibody
😃Good
Catalog No. TMAB-01273
Alias XBR, X2 Box Repressor, REST, Repressor Binding To The X2 Box, RE1-Silencing Transcription Factor, NRSF, Neural-Restrictive Silencer Factor
Anti-NRSF Polyclonal Antibody is a Rabbit antibody targeting NRSF. Anti-NRSF Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P, IP, WB.
Anti-NRSF Polyclonal Antibody
Anti-NRSF Polyclonal Antibody
😃Good
Catalog No. TMAB-01273Alias XBR, X2 Box Repressor, REST, Repressor Binding To The X2 Box, RE1-Silencing Transcription Factor, NRSF, Neural-Restrictive Silencer Factor
Anti-NRSF Polyclonal Antibody is a Rabbit antibody targeting NRSF. Anti-NRSF Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P, IP, WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NRSF Polyclonal Antibody is a Rabbit antibody targeting NRSF. Anti-NRSF Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P, IP, WB. |
| Synonyms | XBR, X2 Box Repressor, REST, Repressor Binding To The X2 Box, RE1-Silencing Transcription Factor, NRSF, Neural-Restrictive Silencer Factor |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit) |
| Verified Activity | 1. Sample: Raji (Human) Cell Lysate at 30 μg Primary: Anti-NRSF (TMAB-01273) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 121 kDa Observed band size: 121 kDa 2. NRSF was immunoprecipitated from human hela cells lysate with TMAB-01273 at 1/150 dilution. Western blot was performed from the immunoprecipitate using protein A/G beads. HRP Conjugated Mouse anti-Rabbit IgG (Light Chain specific) was used as secondary antibody at 1:5000 dilution. Lane 1: human hela cells lysate 10 µg (Input). Lane 2: TMAB-01273 IP in human hela cells lysate. Lane 3: native rabbit IgG IP in human hela cells lysate (negative control). Secondary All Lanes: Mouse anti-Rabbit IgG (Light Chain specific), HRP Conjugated, 1:5000 3. Sample: Hela (Human) Cell Lysate at 30 μg Hela KO NRSF (Human) Cell Lysate at 30 μg Primary: Anti-NRSF (TMAB-01273) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 121 kDa Observed band size: 121 kDa    |
| Application | |
| Recommended Dose | IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; IP=1:50-200; WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010] |
| Immunogen | KLH conjugated synthetic peptide: human NRSF |
| Antigen Species | Human |
| Gene Name | REST |
| Gene ID | |
| Protein Name | RE1-silencing transcription factor |
| Uniprot ID | |
| Biology Area | Co-factors,Zinc Finger,Neurogenesis |
| Function | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. |
| Molecular Weight | Theoretical: 121 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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