Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC-IN-51 is an HDAC inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 430.00 | |
10 mg | In stock | $ 636.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,360.00 | |
100 mg | In stock | $ 1,830.00 | |
500 mg | In stock | $ 3,680.00 |
Description | HDAC-IN-51 is an HDAC inhibitor. |
Targets&IC50 | HDAC10:0.32 Μm, HDAC1:0.353 μM, HDAC2:0.431 μM, HDAC3:0.515 μM, HDAC11:85.4 μM |
In vitro |
HDAC-IN-51 (compound 8d) (1 nM-10 μM; 48 h) has antiproliferative activity with IC50 values of 0.54, 0.56, and 1.35 μM against K562, HCT116, and A549 cells, respectively.[1] HDAC-IN-51 (1, 5 μM; 24, 48 h; U937 leukemia cells) arrests the cell cycle in the G1 phase.[1] HDAC-IN-51 (1, 5 μM; 48 h; U937 cells) induces apoptosis and downregulates miRNAs with anti-apoptotic activity (miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p and miR-21-5p).[1] HDAC-IN-51 (1, 5 μM; 48 h; U937 cells) increases the mRNA expression of p21, BAX, and BAK and downregulates cyclin D1 and BCL-2.[1] |
Molecular Weight | 436.51 |
Formula | C27H24N4O2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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HDAC-IN-51 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC inhibitor inhibit