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HDAC-IN-51

Name: HDAC-IN-51
Brand: TargetMol
SKU: T73181
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73181

HDAC-IN-51 is an HDAC inhibitor.

HDAC-IN-51

😃Good

Purity: 98.85%

Catalog No. T73181

HDAC-IN-51 is an HDAC inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$258	-	In Stock
10 mg	$382	-	In Stock
25 mg	$592	-	In Stock
50 mg	$816	-	In Stock
100 mg	$1,090	-	In Stock
200 mg	$1,480	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.85%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HDAC-IN-51 is an HDAC inhibitor.
Targets&IC50	HDAC2:0.431 μM, HDAC11:85.4 μM, HDAC1:0.353 μM, HDAC10:0.32 Μm, HDAC3:0.515 μM
In vitro	HDAC-IN-51 (compound 8d) (1 nM-10 μM; 48 h) has antiproliferative activity with IC50 values of 0.54, 0.56, and 1.35 μM against K562, HCT116, and A549 cells, respectively.[1] HDAC-IN-51 (1, 5 μM; 24, 48 h; U937 leukemia cells) arrests the cell cycle in the G1 phase.[1] HDAC-IN-51 (1, 5 μM; 48 h; U937 cells) induces apoptosis and downregulates miRNAs with anti-apoptotic activity (miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p and miR-21-5p).[1] HDAC-IN-51 (1, 5 μM; 48 h; U937 cells) increases the mRNA expression of p21, BAX, and BAK and downregulates cyclin D1 and BCL-2.[1]

Chemical Properties

Molecular Weight	436.51
Formula	C₂₇H₂₄N₄O₂
Smiles	O=C(NC1=CC=C(C(NC2=CC=CC=C2N)=O)N=C1)C(C3=CC=CC=C3)CC4=CC=CC=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (103.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2909 mL	11.4545 mL	22.9090 mL	114.5449 mL
5 mM	0.4582 mL	2.2909 mL	4.5818 mL	22.9090 mL
10 mM	0.2291 mL	1.1454 mL	2.2909 mL	11.4545 mL
20 mM	0.1145 mL	0.5727 mL	1.1454 mL	5.7272 mL
50 mM	0.0458 mL	0.2291 mL	0.4582 mL	2.2909 mL
100 mM	0.0229 mL	0.1145 mL	0.2291 mL	1.1454 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc