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Iodoacetyl-LC-Biotin

🥰Excellent
Catalog No. T19956Cas No. 93285-75-7
Alias Iaa-Biotin

Iodoacetyl-LC-Biotin (Iaa-Biotin) is a biotinylated and haloacetyl-activated sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH (7.5-8.5), is membrane-permeable, and can be used to label protein cysteines and other sulfhydryl-containing molecules.

Iodoacetyl-LC-Biotin

Iodoacetyl-LC-Biotin

🥰Excellent
Purity: 97.47%
Catalog No. T19956Alias Iaa-BiotinCas No. 93285-75-7
Iodoacetyl-LC-Biotin (Iaa-Biotin) is a biotinylated and haloacetyl-activated sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH (7.5-8.5), is membrane-permeable, and can be used to label protein cysteines and other sulfhydryl-containing molecules.
Pack SizePriceAvailabilityQuantity
1 mg$397In Stock
5 mg$970In Stock
10 mg$1,290In Stock
25 mg$1,950In Stock
50 mg$2,620In Stock
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Purity:97.47%
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Product Introduction

Bioactivity
Description
Iodoacetyl-LC-Biotin (Iaa-Biotin) is a biotinylated and haloacetyl-activated sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH (7.5-8.5), is membrane-permeable, and can be used to label protein cysteines and other sulfhydryl-containing molecules.
In vitro
Iodoacetyl-LC-Biotin (50-200 μM, 6-24 h) induces dose- and time-dependent cytotoxicity in HEK293 cells. Iodoacetyl-LC-Biotin causes LDH leakage (19-39% at 24 h), mitochondrial cytochrome c release, caspase-3 activation, and PARP cleavage[1]。
AliasIaa-Biotin
Chemical Properties
Molecular Weight510.43
FormulaC18H31IN4O3S
Cas No.93285-75-7
SmilesC(CCCC(NCCCCCCNC(CI)=O)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
Relative Density.1.414g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16 mg/mL (31.35 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9591 mL9.7957 mL19.5913 mL97.9566 mL
5 mM0.3918 mL1.9591 mL3.9183 mL19.5913 mL
10 mM0.1959 mL0.9796 mL1.9591 mL9.7957 mL
20 mM0.0980 mL0.4898 mL0.9796 mL4.8978 mL

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