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Iodoacetyl-LC-Biotin (Iaa-Biotin) is a biotinylated and haloacetyl-activated sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH (7.5-8.5), is membrane-permeable, and can be used to label protein cysteines and other sulfhydryl-containing molecules.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $397 | In Stock | |
5 mg | $970 | In Stock | |
10 mg | $1,290 | In Stock | |
25 mg | $1,950 | In Stock | |
50 mg | $2,620 | In Stock |
Description | Iodoacetyl-LC-Biotin (Iaa-Biotin) is a biotinylated and haloacetyl-activated sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH (7.5-8.5), is membrane-permeable, and can be used to label protein cysteines and other sulfhydryl-containing molecules. |
In vitro | Iodoacetyl-LC-Biotin (50-200 μM, 6-24 h) induces dose- and time-dependent cytotoxicity in HEK293 cells. Iodoacetyl-LC-Biotin causes LDH leakage (19-39% at 24 h), mitochondrial cytochrome c release, caspase-3 activation, and PARP cleavage[1]。 |
Alias | Iaa-Biotin |
Molecular Weight | 510.43 |
Formula | C18H31IN4O3S |
Cas No. | 93285-75-7 |
Smiles | C(CCCC(NCCCCCCNC(CI)=O)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H] |
Relative Density. | 1.414g/cm3 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
Solubility Information | DMSO: 16 mg/mL (31.35 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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