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NFATc1-IN-1

Catalog No. T61531 CAS 1912422-56-0

NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1].

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NFATc1-IN-1, CAS 1912422-56-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 372.00
500 mg	In stock	$ 869.00

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Purity: 99.64%

Biological Description

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Storage & Solubility Information

Description	NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1].
Targets&IC50	Osteoclast:1.57 μM
In vitro	NFATc1-IN-1 (0、0.5、1.0、1.5、2.0、2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption while showing no cytotoxic effects towards osteoclast precursor cells at concentrations of as high as 2.5 μM.[1] NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1.[1]

Molecular Weight	375.11
Formula	C13H8F2INO2
CAS No.	1912422-56-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (299.9 mM ), Sonication is recommended.

References and Literature

1. Chen CL, et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur J Med Chem. 2016 ; 117:70-84. 2. Sun J, et al. Histopathologic features of degenerative aortic valve and its mechanisms. Zhonghua Yi Xue Za Zhi. 2013 ; 93(4):280-284.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

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Keywords

NFATc1-IN-1 1912422-56-0 NF-Κb RANKL/RANK inhibitor inhibit

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