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Hydroxocobalamin (Synonyms: Vitamin B12a)

Name: Hydroxocobalamin
Brand: TargetMol
SKU: T78476
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T78476 Copy Product Info

Purity: 99.81%

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Hydroxocobalamin (Vitamin B12a), a member of the vitamin B12 family, is a potent cyanide antidote. It effectively reduces cyanide concentrations in cells and plasma, significantly increasing the survival rate in cases of acute cyanide poisoning. Additionally, Hydroxocobalamin is used to improve the metabolic profile and neurocognitive outcomes associated with newborn Cbl-C defects and can normalize plasma levels in patients with vitamin B12 deficiency. It is also utilized in research concerning metabolic and neurological diseases, though it may be associated with the induction of acute kidney injury (AKI).

Hydroxocobalamin

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Catalog No. T78476

Synonyms Vitamin B12a

Cas No. 13422-51-0

Pack Size	Price	USA Stock	Global Stock
2 mg	$35	-	In Stock
5 mg	$56	-	In Stock
10 mg	$98	-	In Stock
25 mg	$177	-	In Stock
50 mg	$289	-	In Stock
100 mg	$428	-	In Stock
1 mL x 10 mM (in DMSO)	$146	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:Purple

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Hydroxocobalamin (Vitamin B12a), a member of the vitamin B12 family, is a potent cyanide antidote. It effectively reduces cyanide concentrations in cells and plasma, significantly increasing the survival rate in cases of acute cyanide poisoning. Additionally, Hydroxocobalamin is used to improve the metabolic profile and neurocognitive outcomes associated with newborn Cbl-C defects and can normalize plasma levels in patients with vitamin B12 deficiency. It is also utilized in research concerning metabolic and neurological diseases, though it may be associated with the induction of acute kidney injury (AKI).
In vitro	In vitro, Hydroxocobalamin (1 mM, 5 min) significantly reverses the decrease in cardiac papillary muscle contractility induced by sodium cyanide. In fibroblast models, Hydroxocobalamin (500 microM, 10 min) effectively reduces the accumulation of intracellular cyanide [1].
In vivo	In vivo, intravenous injection of Hydroxocobalamin (150 mg/kg) maintains higher systolic blood pressure in both volume-controlled and uncontrolled hemorrhage swine models, with efficacy comparable to whole blood [2].
Synonyms	Vitamin B12a

Chemical Properties

Molecular Weight	1346.36
Formula	C₆₂H₈₉CoN₁₃O₁₅P
Cas No.	13422-51-0
Smiles	O=C(N)CCC1C=2C=C3[N]4=C(C(=C5[N-]6C7C(CC(=O)N)C5(C)CCC(=O)NCC(OP(=O)([O-])OC8C(O)C(OC8CO)N9C=[N](C=%10C=C(C(=CC%109)C)C)[Co+3]4%116([OH-])[N]2C(=C(C%12=[N]%11C7(C)C(C)(CC(=O)N)C%12CCC(=O)N)C)C1(C)CC(=O)N)C)C)C(CCC(=O)N)C3(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (14.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7427 mL	3.7137 mL	7.4274 mL	37.1372 mL
5 mM	0.1485 mL	0.7427 mL	1.4855 mL	7.4274 mL
10 mM	0.0743 mL	0.3714 mL	0.7427 mL	3.7137 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc