LRP-5 Protein, Human, Recombinant (hFc)

Name: LRP-5 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPK-00739
Rating: 4.5 (1 reviews)

(Synonyms: VBCH2, OPTA1, OPS, OPPG, LRP-7, LRP7, LRP-5, LRP5, LR3VBCH2, LR3, HBM, EVR4, EVR1, BMND1OPTA1, BMND1) Copy Product Info

Synonyms: VBCH2, OPTA1, OPS, OPPG, LRP-7, LRP7, LRP-5, LRP5, LR3VBCH2, LR3, HBM, EVR4, EVR1, BMND1OPTA1, BMND1

Catalog No. TMPK-00739 Copy Product Info

A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.

Pack Size	Price	USA Stock	Global Stock
10 µg	$92	7-10 days	7-10 days
20 µg	$148	7-10 days	7-10 days
50 µg	$289	7-10 days	7-10 days
100 µg	$487	7-10 days	7-10 days
200 µg	$883	7-10 days	7-10 days
500 µg	$1,950	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Immobilized Human DKK1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human LPR-5, hFc Tag with the EC50 of 1.04μg/ml determined by ELISA. 2. Human LRP-5, hFc Tag captured on CM5 Chip via Protein A can bind Human DKK1, His Tag with an affinity constant of 0.28 μM as determined in SPR assay.
Description	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	O75197-1
Construction	Glu644-Gln1263
Protein Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS, 100 mM L-arginine (pH 7.4).
Synonyms	VBCH2, OPTA1, OPS, OPPG, LRP-7, LRP7, LRP-5, LRP5, LR3VBCH2, LR3, HBM, EVR4, EVR1, BMND1OPTA1, BMND1
Research Background	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.

Chemical Properties

Molecular Weight

96.51 kDa (predicted). Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.