A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 487.00 | |
500 μg | 5 days | $ 1,950.00 | |
1 mg | 5 days | $ 3,250.00 |
Description | A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-hFc |
Accession Number | O75197-1 |
Synonyms | EVR1, BMND1, BMND1OPTA1, LRP5, LRP7, OPPG, EVR4, OPTA1, OPS, HBM, VBCH2, LR3VBCH2, LRP-7, LR3, LRP-5 |
Construction | Glu644-Gln1263 |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | 96.51 kDa (predicted). Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result. |
Endotoxin | < 1 EU/μg by the LAL method. |
Formulation | Supplied as 0.22 μm filtered solution in PBS, 100 mM L-arginine (pH 7.4). |
Stability & Storage |
It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 12 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
LRP-5 Protein, Human, Recombinant (hFc) OPTA 1 EVR1 VBCH-2 VBCH 2 BMND1 BMND1OPTA1 LR-3 OPTA-1 EVR 1 EVR-1 LRP5 LRP7 OPPG LRP 7 EVR4 EVR 4 OPTA1 OPS HBM VBCH2 LR3VBCH2 LRP-7 LR3 BMND 1 BMND-1 LRP-5 EVR-4 LRP 5 LR 3 recombinant recombinant-proteins proteins protein