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NF-κΒ activator 2

Name: NF-κΒ activator 2
Brand: TargetMol
SKU: T39924
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39924Cas No. 2375281-44-8

NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1].

NF-κΒ activator 2

🥰Excellent

Purity: 98.12%

Catalog No. T39924Cas No. 2375281-44-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$95	In Stock	In Stock
2 mg	$138	In Stock	In Stock
5 mg	$238	In Stock	In Stock
10 mg	$353	In Stock	In Stock
25 mg	$567	In Stock	In Stock
50 mg	$768	In Stock	In Stock
100 mg	$987	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$262	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.12%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1].
Targets&IC50	NF-κB:1.58 μM (EC50)
In vitro	NF-κB activator 2 (Compound 61) (1 μM, 6 hr) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells [1]. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through the activation of NF-ҡBs.
In vivo	NF-κΒ activator 2, when administered intravenously (i.v.) at a dose of 1 mg/kg, demonstrates an appropriate half-life of 0.96 hours in mice [1]. Similarly, at an oral (p.o.) dosage of 5 mg/kg, it shows a comparable half-life of 2.86 hours, an oral bioavailability of 15.6%, and a maximum concentration (C max) of 92 ng/mL [1].

Chemical Properties

Molecular Weight	298.27
Formula	C₁₆H₁₁FN₂O₃
Cas No.	2375281-44-8
Smiles	OC(=O)c1cccc(c1)-c1cnc(Nc2ccccc2F)o1
Relative Density.	1.396 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (838.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3527 mL	16.7633 mL	33.5267 mL	167.6334 mL
5 mM	0.6705 mL	3.3527 mL	6.7053 mL	33.5267 mL
10 mM	0.3353 mL	1.6763 mL	3.3527 mL	16.7633 mL
20 mM	0.1676 mL	0.8382 mL	1.6763 mL	8.3817 mL
50 mM	0.0671 mL	0.3353 mL	0.6705 mL	3.3527 mL
100 mM	0.0335 mL	0.1676 mL	0.3353 mL	1.6763 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc