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Estrone O-sulfamate

🥰Excellent
Catalog No. T72470Cas No. 148672-09-7
Alias Estrone 3-O-sulfamate

Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS), showing IC50 values of 18 nM as a placental microsomal inhibitor (P.M.) and 0.83 nM in MCF-7 cells. Estrone O-sulfamate can be used to study cancer.

Estrone O-sulfamate

Estrone O-sulfamate

🥰Excellent
Purity: 99.86%
Catalog No. T72470Alias Estrone 3-O-sulfamateCas No. 148672-09-7
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS), showing IC50 values of 18 nM as a placental microsomal inhibitor (P.M.) and 0.83 nM in MCF-7 cells. Estrone O-sulfamate can be used to study cancer.
Pack SizePriceAvailabilityQuantity
1 mg$138In Stock
5 mg$330In Stock
10 mg$410In Stock
25 mg$538In Stock
50 mg$685In Stock
100 mg$826In Stock
200 mg$1,160In Stock
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Purity:99.86%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS), showing IC50 values of 18 nM as a placental microsomal inhibitor (P.M.) and 0.83 nM in MCF-7 cells. Estrone O-sulfamate can be used to study cancer.
Targets&IC50
STS (MCF-7 cells):0.83 nM, STS (P.M.):18 nM
In vitro
In both placental microsome (P.M.) preparations and MCF-7 cells, Estrone O-sulfamate (Estrone 3-O-sulfamate) exhibits inhibitory activity against STS, with IC50 values of 18 nM and 0.83 nM, respectively[1].
SynonymsEstrone 3-O-sulfamate
Chemical Properties
Molecular Weight349.44
FormulaC18H23NO4S
Cas No.148672-09-7
SmilesC[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OS(N)(=O)=O)=CC4)(CC1)[H])[H])(CCC2=O)[H]
Relative Density.1.314 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (157.39 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8617 mL14.3086 mL28.6172 mL143.0861 mL
5 mM0.5723 mL2.8617 mL5.7234 mL28.6172 mL
10 mM0.2862 mL1.4309 mL2.8617 mL14.3086 mL
20 mM0.1431 mL0.7154 mL1.4309 mL7.1543 mL
50 mM0.0572 mL0.2862 mL0.5723 mL2.8617 mL
100 mM0.0286 mL0.1431 mL0.2862 mL1.4309 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

STSEstrone O-sulfamate
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