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Estrone O-sulfamate

Name: Estrone O-sulfamate
Brand: TargetMol
SKU: T72470
Price: 138 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72470Cas No. 148672-09-7

Alias Estrone 3-O-sulfamate

Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS), showing IC50 values of 18 nM as a placental microsomal inhibitor (P.M.) and 0.83 nM in MCF-7 cells. Estrone O-sulfamate can be used to study cancer.

Estrone O-sulfamate

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Purity: 99.89%

Catalog No. T72470Alias Estrone 3-O-sulfamateCas No. 148672-09-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$138	-	In Stock
5 mg	$330	-	In Stock
10 mg	$410	-	In Stock
25 mg	$538	-	In Stock
50 mg	$685	-	In Stock
100 mg	$826	-	In Stock
200 mg	$1,160	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS), showing IC50 values of 18 nM as a placental microsomal inhibitor (P.M.) and 0.83 nM in MCF-7 cells. Estrone O-sulfamate can be used to study cancer.
Targets&IC50	STS (MCF-7 cells):0.83 nM, STS (P.M.):18 nM
In vitro	In both placental microsome (P.M.) preparations and MCF-7 cells, Estrone O-sulfamate (Estrone 3-O-sulfamate) exhibits inhibitory activity against STS, with IC50 values of 18 nM and 0.83 nM, respectively[1].
Synonyms	Estrone 3-O-sulfamate

Chemical Properties

Molecular Weight	349.44
Formula	C₁₈H₂₃NO₄S
Cas No.	148672-09-7
Smiles	C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OS(N)(=O)=O)=CC4)(CC1)[H])[H])(CCC2=O)[H]
Relative Density.	1.314 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (157.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8617 mL	14.3086 mL	28.6172 mL	143.0861 mL
5 mM	0.5723 mL	2.8617 mL	5.7234 mL	28.6172 mL
10 mM	0.2862 mL	1.4309 mL	2.8617 mL	14.3086 mL
20 mM	0.1431 mL	0.7154 mL	1.4309 mL	7.1543 mL
50 mM	0.0572 mL	0.2862 mL	0.5723 mL	2.8617 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4309 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc