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TH287 hydrochloride

Name: TH287 hydrochloride
Brand: TargetMol
SKU: T2069L
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2069LCas No. 1638211-05-8

TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

TH287 hydrochloride

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Catalog No. T2069LCas No. 1638211-05-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
2 mg	$64	In Stock	In Stock
5 mg	$92	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$251	In Stock	In Stock
50 mg	$375	In Stock	-
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Targets&IC50	MTH1:0.8 nM
In vitro	TH287 as first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 protein in cells.?Protein co-crystal structures demonstrate that the inhibitors bind in the active site of MTH1.?The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts[1].

Chemical Properties

Molecular Weight	305.59
Formula	C₁₁H₁₁Cl₃N₄
Cas No.	1638211-05-8
Smiles	NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (89.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2724 mL	16.3618 mL	32.7236 mL	163.6179 mL
5 mM	0.6545 mL	3.2724 mL	6.5447 mL	32.7236 mL
10 mM	0.3272 mL	1.6362 mL	3.2724 mL	16.3618 mL
20 mM	0.1636 mL	0.8181 mL	1.6362 mL	8.1809 mL
50 mM	0.0654 mL	0.3272 mL	0.6545 mL	3.2724 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc