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ADAM15 Protein, Human, Recombinant (His)

Catalog No. TMPY-00961
Synonyms: MDC15, ADAM metallopeptidase domain 15

ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10.

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ADAM15 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 357.00
100 μg 5 days $ 700.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number Q13444-10
Synonyms MDC15, ADAM metallopeptidase domain 15
Construction Human ADAM15 (NP_997074.1) (Met 1-Thr 696) precursor with a C-terminal polyhistidine tag
Protein Purity > 97 % as determined by SDS-PAGE
Molecular Weight 54 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.

References and Literature

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Keywords

ADAM15 Protein, Human, Recombinant (His) MDC15 MDC-15 MDC 15 ADAM metallopeptidase domain 15 recombinant recombinant-proteins proteins protein

 

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