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GSK251

Catalog No. T39573 CAS 2125968-05-8

GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.

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GSK251, CAS 2125968-05-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 278.00
5 mg	In stock	$ 695.00
10 mg	In stock	$ 988.00
25 mg	In stock	$ 1,470.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,670.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.

Molecular Weight	584.71
Formula	C29H37FN6O4S
CAS No.	2125968-05-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (85.5 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Down K, et al. Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode. J Med Chem. 2021 Sep 23;64(18):13780-13792.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Kinase Inhibitor Library Inhibitor Library Anti-Breast Cancer Compound Library Bioactive Compound Library Anti-Lung Cancer Compound Library Antioxidant Compound Library Bioactive Compounds Library Max Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library

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Related compounds with same targets

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK251 2125968-05-8 PI3K/Akt/mTOR signaling PI3K GSK 251 GSK-251 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.