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Lys-Phe-Glu-Arg-Gln
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Catalog No. T81894 Copy Product Info
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Lys-Phe-Glu-Arg-Gln is a synthetic pentapeptide that corresponds to the KFERQ-like motif recognized by the chaperone-mediated autophagy pathway. It functions as a specific targeting signal, directing cytosolic proteins containing this sequence to lysosomes for degradation, with over 30% of cytosolic proteins in liver identified as KFERQ-containing substrates. In fasting models, this pathway accounts for up to 80% of enhanced liver proteolysis after 48 hours, while being selectively upregulated in heart but not skeletal muscle. Researchers use this peptide to study selective protein turnover mechanisms, cellular stress responses, and tissue-specific regulation of lysosomal degradation pathways.
Cas No. 115084-19-0
| Pack Size | Price | EUR Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Lys-Phe-Glu-Arg-Gln is a synthetic pentapeptide that corresponds to the KFERQ-like motif recognized by the chaperone-mediated autophagy pathway. It functions as a specific targeting signal, directing cytosolic proteins containing this sequence to lysosomes for degradation, with over 30% of cytosolic proteins in liver identified as KFERQ-containing substrates. In fasting models, this pathway accounts for up to 80% of enhanced liver proteolysis after 48 hours, while being selectively upregulated in heart but not skeletal muscle. Researchers use this peptide to study selective protein turnover mechanisms, cellular stress responses, and tissue-specific regulation of lysosomal degradation pathways. |
| Molecular Weight | 706.79 |
| Formula | C31H50N10O9 |
| Cas No. | 115084-19-0 |
| Smiles | [C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)NC([C@H](CCCCN)N)=O |
| Sequence | Lys-Phe-Glu-Arg-Gln |
| Sequence Short | KFERQ |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Related Tags: Lys-Phe-Glu-Arg-Gln chemical structure | Lys-Phe-Glu-Arg-Gln formula | Lys-Phe-Glu-Arg-Gln molecular weight
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