LIGHT/TNFSF14 Protein, Human, Recombinant

Name: LIGHT/TNFSF14 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPS-00098
Rating: 4.5 (1 reviews)

(Synonyms: HVEM-L, LTg, TNFSF14, TR2, HVEML, CD258 antigen, CD258) Copy Product Info

Synonyms: HVEM-L, LTg, TNFSF14, TR2, HVEML, CD258 antigen, CD258

Catalog No. TMPS-00098 Copy Product Info

LIGHT/TNFSF14 Protein, Human, Recombinant is expressed in HEK293 Cells. The accession number is O43557.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$70	7-10 days	7-10 days
10 µg	$112	7-10 days	7-10 days
20 µg	$183	7-10 days	7-10 days
50 µg	$360	7-10 days	7-10 days
100 µg	$498	7-10 days	7-10 days
200 µg	$883	7-10 days	7-10 days
500 µg	$1,890	7-10 days	7-10 days
1 mg	$3,390	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized LIGHT, Human at 2.0 μg/ml (100 μl/well) can bind HVEM-Fc, Human with EC 50 =0.738 µg/ml when detected by Mouse Anti-Human IgG FC-HRP.
Description	LIGHT/TNFSF14 Protein, Human, Recombinant is expressed in HEK293 Cells. The accession number is O43557.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	O43557
Construction	Asp74 - Val240
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	HVEM-L, LTg, TNFSF14, TR2, HVEML, CD258 antigen, CD258
Research Background	LIGHT, also known as tumor-necrosis factor (TNF) superfamily member 14 (TNFSF14), is predominantly expressed on activated immune cells and some tumor cells. LIGHT (homologous to lymphotoxin, exhibits inducible expression and competes with Herpes Simplex Virus glycoprotein D for Herpes Virus Entry Mediator, a receptor expressed by T cells), is a protein primarily expressed on activated T cells, activated Natural Killer (NK) cells, and immature dendritic cells (DC). LIGHT can function as both a soluble and cell surface-bound type II membrane protein and must be in its homotrimeric form to interact with its two primary functional receptors: Herpes Virus Entry Mediator (HVEM) and Lymphotoxin-β Receptor (LTβR). LIGHT signaling through these receptors have distinct functions that are cell-type dependent, but interactions with both types of receptors have immune-related implications in tumor biology.

Chemical Properties

Molecular Weight

~15.6 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.