Oxitropium Bromide

Name: Oxitropium Bromide
Brand: TargetMol
SKU: T16417
Rating: 4.5 (1 reviews)

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Catalog No. T16417Cas No. 30286-75-0

Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.

Oxitropium Bromide

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Catalog No. T16417Cas No. 30286-75-0

Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.

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Product Introduction

Bioactivity

Description	Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.
In vitro	Incubation with Oxitropium bromide of the untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro; but, it induces both types of muscle to be fatigue resistant. Oxitropium bromide is a muscarinic antagonist that blocks musucarinic acetylcholine receptors (mAChR) [1].
In vivo	Oxitropium bromide effectively and durably counteracts the increase in resistance caused by acetylcholine (ACh), alongside inhibiting resistance spikes triggered by histamine, serotonin, leukotriene D4, or antigens. This compound, when inhaled, enhances force-frequency curves two hours post-administration and mitigates the reduction of these curves following endotoxin exposure in vivo. Furthermore, inhaling Oxitropium bromide at dosages of 1.5 μg or more significantly reduces the decline in mucus score due to intravenous histamine, albeit this effect is not observed with histamine inhalation [1][2][3].

Chemical Properties

Molecular Weight	412.32
Formula	C₁₉H₂₆BrNO₄
Cas No.	30286-75-0
Smiles	C(C)[N@+]1(C)[C@H]2[C@@]3([C@@](O3)([C@@H]1C[C@H](OC([C@H](CO)C4=CC=CC=C4)=O)C2)[H])[H].[Br-]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc