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Nomegestrol

Name: Nomegestrol
Brand: TargetMol
SKU: T19811
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19811Cas No. 58691-88-6

Alias TX 066 free base

Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.Nomegestrol is also a contraceptive progestin and is used in the study of endometriosis and meningiomas.

Nomegestrol

🥰Excellent

Catalog No. T19811Alias TX 066 free baseCas No. 58691-88-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$295	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.Nomegestrol is also a contraceptive progestin and is used in the study of endometriosis and meningiomas.
Targets&IC50	uterine progesterone receptor (rat):5.44 nM (Kd)
In vitro	Nomegestrol is a highly selective full agonist at the progesterone receptor but has little or no binding affinity for other steroid receptors such as the androgen and glucocorticoid receptors. [1] Nomegestrol is a progestin with a high binding affinity for the progesterone receptor and a Kd of 5.44 nM for the rat uterine progesterone receptor. [2]
In vivo	In animal models, Nomegestrol demonstrated moderate antiandrogenic activity and strong antiestrogenic activity. [1]
Synonyms	TX 066 free base

Chemical Properties

Molecular Weight	328.45
Formula	C₂₁H₂₈O₃
Cas No.	58691-88-6
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@@]4(C(C(C)=C3)=CC(=O)CC4)[H])(CC1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (24.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0446 mL	15.2230 mL	30.4460 mL	152.2302 mL
5 mM	0.6089 mL	3.0446 mL	6.0892 mL	30.4460 mL
10 mM	0.3045 mL	1.5223 mL	3.0446 mL	15.2230 mL
20 mM	0.1522 mL	0.7612 mL	1.5223 mL	7.6115 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc