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CRAC intermediate 1

Name: CRAC intermediate 1
Brand: TargetMol
SKU: T10884
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10884Cas No. 1249343-86-9

Alias 5-(S)-Fluorowillardiine

CRAC intermediate 1 is a key intermediate used in the synthesis of the CRAC ion channel series of compounds, details from patent WO 2010122089.

CRAC intermediate 1

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Purity: 99.77%

Catalog No. T10884Alias 5-(S)-FluorowillardiineCas No. 1249343-86-9

CRAC intermediate 1 is a key intermediate used in the synthesis of the CRAC ion channel series of compounds, details from patent WO 2010122089.

Pack Size	Price	Availability
10 mg	$33	In Stock
25 mg	$62	In Stock
50 mg	$98	In Stock
100 mg	$148	In Stock
200 mg	$221	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.77%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CRAC intermediate 1 is a key intermediate used in the synthesis of the CRAC ion channel series of compounds, details from patent WO 2010122089.
Synonyms	5-(S)-Fluorowillardiine

Chemical Properties

Molecular Weight	223.18
Formula	C₁₀H₇F₂N₃O
Cas No.	1249343-86-9
Smiles	Fc1cccc(F)c1C(=O)Nc1cc[nH]n1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (224.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4807 mL	22.4034 mL	44.8069 mL	224.0344 mL
5 mM	0.8961 mL	4.4807 mL	8.9614 mL	44.8069 mL
10 mM	0.4481 mL	2.2403 mL	4.4807 mL	22.4034 mL
20 mM	0.2240 mL	1.1202 mL	2.2403 mL	11.2017 mL
50 mM	0.0896 mL	0.4481 mL	0.8961 mL	4.4807 mL
100 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc