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OBA-09

Name: OBA-09
Brand: TargetMol
SKU: T16371
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16371Cas No. 856095-68-6

OBA-09 (2-oxopropanoyloxy benzoic acid) is a novel multimodal neuroprotectant synthesized as a hybrid of salicylic acid and pyruvate. Designed to synergize the anti-inflammatory properties of salicylic acid with the metabolic support and antioxidant capacity of pyruvate, OBA-09 combats ischemic brain injury effectively. It exhibits potent radical scavenging activity against superoxide, hydroxyl radicals, and hydrogen peroxide. Furthermore, it attenuates post-ischemic inflammation by inhibiting the NF-kB signaling pathway and the release of HMGB1. In stroke models, OBA-09 significantly reduces infarct volume and improves neurological scores.

OBA-09

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Purity: 99.01%

Catalog No. T16371Cas No. 856095-68-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$55	-	In Stock
10 mg	$89	-	In Stock
25 mg	$148	-	In Stock
50 mg	$219	-	In Stock
100 mg	$326	-	In Stock
1 mL x 10 mM (in DMSO)	$61	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.01%

Appearance:Solid

Color:Gray

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	OBA-09 (2-oxopropanoyloxy benzoic acid) is a novel multimodal neuroprotectant synthesized as a hybrid of salicylic acid and pyruvate. Designed to synergize the anti-inflammatory properties of salicylic acid with the metabolic support and antioxidant capacity of pyruvate, OBA-09 combats ischemic brain injury effectively. It exhibits potent radical scavenging activity against superoxide, hydroxyl radicals, and hydrogen peroxide. Furthermore, it attenuates post-ischemic inflammation by inhibiting the NF-kB signaling pathway and the release of HMGB1. In stroke models, OBA-09 significantly reduces infarct volume and improves neurological scores.
In vitro	In cell-free assays, OBA-09 acted as a robust ROS scavenger, effectively neutralizing hydroxyl radicals (OH), superoxide anions (O2.-), and hydrogen peroxide (H2O2). In neuronal cultures, it inhibited the DNA binding activity of NF-kB and suppressed the degradation of IkB-alpha, leading to decreased expression of proinflammatory enzymes like iNOS and COX-2 [1][2].
In vivo	In a rat model of middle cerebral artery occlusion (MCAO), systemic administration of OBA-09 (50-100 mg/kg, intraperitoneal) significantly reduced brain infarct volume and improved neurological deficits. It effectively lowered the levels of proinflammatory cytokines (IL-1beta, TNF-alpha) and prevented the nucleocytoplasmic translocation and subsequent release of HMGB1 in the ischemic brain [1][2].

Chemical Properties

Molecular Weight	208.17
Formula	C₁₀H₈O₅
Cas No.	856095-68-6
Smiles	O=C(O)C=1C=CC=CC1OC(=O)C(=O)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (384.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.4 mg/mL (11.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8038 mL	24.0188 mL	48.0377 mL	240.1883 mL
5 mM	0.9608 mL	4.8038 mL	9.6075 mL	48.0377 mL
10 mM	0.4804 mL	2.4019 mL	4.8038 mL	24.0188 mL
20 mM	0.2402 mL	1.2009 mL	2.4019 mL	12.0094 mL
50 mM	0.0961 mL	0.4804 mL	0.9608 mL	4.8038 mL
100 mM	0.0480 mL	0.2402 mL	0.4804 mL	2.4019 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OBA-09OBA09OBA 09