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WAY 316606 HCl (915759-45-4 free base)

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Catalog No. T23529
Alias WAY 316606 HCl

WAY 316606 HCl is a selective small-molecule inhibitor of secreted frizzled-related protein-1 (EC50: 0.65 μM).

WAY 316606 HCl (915759-45-4 free base)
Other Forms of WAY 316606 HCl (915759-45-4 free base):

WAY 316606 HCl (915759-45-4 free base)

😃Good
Catalog No. T23529Alias WAY 316606 HCl
WAY 316606 HCl is a selective small-molecule inhibitor of secreted frizzled-related protein-1 (EC50: 0.65 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$1818-10 weeks8-10 weeks
10 mg$2888-10 weeks8-10 weeks
50 mg$1,1468-10 weeks8-10 weeks
100 mg$1,8328-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
WAY 316606 HCl is a selective small-molecule inhibitor of secreted frizzled-related protein-1 (EC50: 0.65 μM).
In vitro
WAY 316606 HCl is a selective inhibitor of sFRP-1. It bound to sFRP-2 with 10-fold weaker affinity (Kd: 1 μM). In a fluorescence polarization binding assay, WAY 316606 HCl inhibited sFRP-1 (IC50: 0.5 μM). Although sequence of sFRP-1, -2 and -5 showed high identity, WAY 316606 HCl selectively inhibited sFRP-1 against other two proteins. In the osteosarcoma U2-OS cell line used in a cell-based transient transfection and luciferase reporter assay, treatment of WAY 316606 HCl dose-dependently increased Wnt-signaling (EC50: 0.65 μM). In an ex vivo assay using neonatal murine calvarium, treatment of WAY 316606 HCl dose-dependently enhanced the osteoblast activity and stimulated bone formation up to 60% (EC50: 1 nM) [1][2].
In vivo
Although WAY 316606 had good aqueous solubility and good stability, WAY 316606 HCl exerted high plasma clearance (77 mL/min/kg) in rats, which suppressed sustained exposure and limited the compound's advancement as an orally administered anabolic bone agent [1].
SynonymsWAY 316606 HCl
Chemical Properties
Molecular Weight484.94
FormulaC18H19F3N2O4S2·HCl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: ≥24.25 mg/mL, Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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