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cGAMP

Name: cGAMP
Brand: TargetMol
SKU: T13606
Rating: 4.5 (1 reviews)

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Catalog No. T13606Cas No. 849214-04-6

Alias Cyclic GMP-AMP, 3',3'-cGAMP

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

cGAMP

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Catalog No. T13606Alias Cyclic GMP-AMP, 3',3'-cGAMPCas No. 849214-04-6

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,420	7-10 days	7-10 days
50 mg	$3,180	7-10 days	7-10 days
100 mg	$4,300	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.
In vitro	cGAMP directly activates murine and human dendritic cells in vitro. cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice [2]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding IL-1, IL-6, or TNF [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4].
In vivo	cGAMP stimulates the antigen-specific cytokine production by spleen cells of immunized mice [2].
Synonyms	Cyclic GMP-AMP, 3',3'-cGAMP

Chemical Properties

Molecular Weight	674.41
Formula	C₂₀H₂₄N₁₀O₁₃P₂
Cas No.	849214-04-6
Smiles	O[C@H]1[C@](N2C3=C(N=C2)C(=O)N=C(N)N3)(O[C@]4([C@]1(OP(=O)(O)OC[C@@]5([C@@](OP(=O)(O)OC4)([C@@H](O)[C@@](O5)(N6C=7C(N=C6)=C(N)N=CN7)[H])[H])[H])[H])[H])[H]
Relative Density.	2.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (29.66 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.4828 mL	7.4139 mL	14.8278 mL	74.1389 mL
5 mM	0.2966 mL	1.4828 mL	2.9656 mL	14.8278 mL
10 mM	0.1483 mL	0.7414 mL	1.4828 mL	7.4139 mL
20 mM	0.0741 mL	0.3707 mL	0.7414 mL	3.7069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc