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Anti-CTLA4 Antibody (3L241)

(Synonyms: IDDM12, ICOS, GSE, GRD4, CTLA4, CELIAC3, CD152, ALPS5) Copy Product Info
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Synonyms: IDDM12, ICOS, GSE, GRD4, CTLA4, CELIAC3, CD152, ALPS5

Catalog No. TMAH-00311 Copy Product Info
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Anti-CTLA4 Antibody (3L241) is an antibody targeting CTLA4. Anti-CTLA4 Antibody (3L241) can be used in ELISA,IHC.

Anti-CTLA4 Antibody
(3L241)

Pack SizePriceUSA StockGlobal StockQuantity
50 µL$2087-10 days7-10 days
100 µL$3477-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-CTLA4 Antibody (3L241) is an antibody targeting CTLA4. Anti-CTLA4 Antibody (3L241) can be used in ELISA,IHC.
SynonymsIDDM12, ICOS, GSE, GRD4, CTLA4, CELIAC3, CD152, ALPS5
Ig Type
Rabbit IgG
Clone
3L241
Reactivity
Human
Verified Activity
1. IHC image of TMAH-00311 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
2. IHC image of TMAH-00311 diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Application
Recommended Dose
IHC:1:50-1:200.
Antibody Type
Monoclonal
Subcellular LocalizationCell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization.
Tissue SpecificityWidely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundInhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthetic peptide: Human CTLA4 (CD152)
Antigen Species
Human
Gene Name
CTLA4
Gene ID
Uniprot ID
Biology Area
Immunology, Stem cells
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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