Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-Nicastrin Antibody (4R415) (Synonyms: RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2)
Catalog No. TMAC-02847 Copy Product Info
🥰Excellent
Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB.
Anti-Nicastrin Antibody (4R415)
Copy Product Info🥰Excellent
Catalog No. TMAC-02847
Synonyms RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2
Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB.
Anti-Nicastrin Antibody
(4R415)
(4R415)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB. |
| Synonyms | RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2 |
| Ig Type | IgG |
| Clone | 4R415 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of Nicastrin on THP-1 cell lysate using anti-Nicastrin antibody at 1/1,000 dilution.  |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the β-Amyloid precursor protein (βAPP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of βAPP and results in the overproduction of the neurotoxic β-Amyloid peptide, which results in a condition associated with Familial Alzheimer's disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of βAPP, which makes nicastrin an attractive potential target for modulating the production of β-Amyloid in patients with Alzheimer's disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites. |
| Conjucates | Unconjugated |
| Immunogen | A synthesized peptide: within Human Nicastrin aa 650-750 (C terminal) |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 78 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
Preview
Related Tags: buy Anti-Nicastrin Antibody (4R415) | purchase Anti-Nicastrin Antibody (4R415) | Anti-Nicastrin Antibody (4R415) cost | order Anti-Nicastrin Antibody (4R415) | Anti-Nicastrin Antibody (4R415) molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.