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Anti-Nicastrin Antibody (4R415)
😃Good
Catalog No. TMAC-02847
Alias RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2
Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB.
Anti-Nicastrin Antibody (4R415)
Anti-Nicastrin Antibody (4R415)
😃Good
Catalog No. TMAC-02847Alias RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2
Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB. |
| Synonyms | RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2 |
| Ig Type | IgG |
| Clone | 4R415 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of Nicastrin on THP-1 cell lysate using anti-Nicastrin antibody at 1/1,000 dilution.  |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the β-Amyloid precursor protein (βAPP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of βAPP and results in the overproduction of the neurotoxic β-Amyloid peptide, which results in a condition associated with Familial Alzheimer's disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of βAPP, which makes nicastrin an attractive potential target for modulating the production of β-Amyloid in patients with Alzheimer's disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites. |
| Conjucates | Unconjugated |
| Immunogen | A synthesized peptide: within Human Nicastrin aa 650-750 (C terminal) |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 78 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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