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LSD1-IN-20

Name: LSD1-IN-20
Brand: TargetMol
SKU: T63140
Price: 397 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63140Cas No. 1239589-91-3

Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, with IC50 of 0.51 and 1.60 μM, respectively, at 72 h.

LSD1-IN-20

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Purity: 99.57%

Catalog No. T63140Cas No. 1239589-91-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$397	In Stock	In Stock
5 mg	$970	In Stock	In Stock
10 mg	$1,180	In Stock	In Stock
25 mg	$1,580	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,500	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.57%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

LSD1-IN-20 AI Summary

LSD1-IN-20 exhibits potent inhibition of human G9a with an IC50 value of 123.0 nM but shows low selectivity for Plasmodium falciparum 3D7, with an IC50 value greater than 1000.0 nM. The compound has notable binding affinity to LSD1/CoREST, with a dissociation constant (Kd) of 243.0 nM, and inhibits LSD1/CoREST with a Ki of 440.0 nM using histone H3 as a substrate. Additionally, LSD1-IN-20 exhibits significant antiproliferative activities against various human cancer cell lines: THP-1 cells with IC50 values between 380.0 nM and 690.0 nM across different time points, MDA-MB-231 cells with an IC50 of 1600.0 nM at 72 hours, RD cells with IC50 values ranging from 2820.0 nM to 6400.0 nM depending on the duration, and Rh30 cells with IC50 values between 2570.0 nM and 4330.0 nM. It also shows cytotoxicity against human derived mesenchymal stem cells, with 85.0% residual viability at 2.5 μM after 72 hours. The compound also manifests antiproliferative activity against human MV4-11 cells with an IC50 of 890.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, with IC50 of 0.51 and 1.60 μM, respectively, at 72 h.
Targets&IC50	LSD1:0.440 μM (Ki), G9a:0.68 μM

Chemical Properties

Molecular Weight	478.63
Formula	C₂₇H₃₈N₆O₂
Cas No.	1239589-91-3
Smiles	N(C=1C2=C(N=C(NCCCN(C)C)N1)C=C(OC)C(OC)=C2)C3CCN(CC4=CC=CC=C4)CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (94.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0893 mL	10.4465 mL	20.8930 mL	104.4648 mL
5 mM	0.4179 mL	2.0893 mL	4.1786 mL	20.8930 mL
10 mM	0.2089 mL	1.0446 mL	2.0893 mL	10.4465 mL
20 mM	0.1045 mL	0.5223 mL	1.0446 mL	5.2232 mL
50 mM	0.0418 mL	0.2089 mL	0.4179 mL	2.0893 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc