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Tenofovir alafenamide hemifumarate (Alias: Tenofovir alafenamide fumarate, GS-7340 (hemifumarate))

Name: Tenofovir alafenamide hemifumarate
Brand: TargetMol
SKU: T7282
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T7282 Copy Product Info

Purity: 99.96%

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Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).

Tenofovir alafenamide hemifumarate

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Catalog No. T7282

Alias Tenofovir alafenamide fumarate, GS-7340 (hemifumarate)

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).

Cas No. 1392275-56-7

Pack Size	Price	USA Stock	Global Stock
5 mg	$39	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$86	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$155	In Stock	In Stock
500 mg	$389	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Color:White

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Product Introduction

Bioactivity

Description	Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).
In vitro	Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).?Overexpression of CatA or liver carboxylesterase 1 (Ces1) in HEK293T cells increased intracellular TAF hydrolysis 2- and 5-fold, respectively.?Knockdown of CatA expression with RNA interference (RNAi) in HeLa cells reduced intracellular TAF metabolism 5-fold.?Additionally, the anti-HIV activity and the rate of CatA hydrolysis showed good correlation within a large set of TFV phosphonoamidate prodrugs[1].
Synonyms	Tenofovir alafenamide fumarate, GS-7340 (hemifumarate)

Chemical Properties

Molecular Weight	534.51
Formula	C₂₁H₂₉N₆O₅P·1/2C₄H₄O₄
Cas No.	1392275-56-7
Smiles	OC(/C=C/C(O)=O)=O.CC(C)OC([C@H](C)NP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(OC3=CC=CC=C3)=O)=O.CC(C)OC([C@H](C)NP(CO[C@H](C)CN4C5=NC=NC(N)=C5N=C4)(OC6=CC=CC=C6)=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (93.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8709 mL	9.3544 mL	18.7087 mL	93.5436 mL
5 mM	0.3742 mL	1.8709 mL	3.7417 mL	18.7087 mL
10 mM	0.1871 mL	0.9354 mL	1.8709 mL	9.3544 mL
20 mM	0.0935 mL	0.4677 mL	0.9354 mL	4.6772 mL
50 mM	0.0374 mL	0.1871 mL	0.3742 mL	1.8709 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tenofovir alafenamide hemifumarateTenofovir alafenamide FumarateTenofovir alafenamideReverseTranscriptaseReverse TranscriptaseInhibitorinhibitHuman immunodeficiency virusHIVProteaseHIV-1HIV ProteaseHIVGS-7340 hemifumarateGS-7340GS7340GS 7340

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