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Tenofovir alafenamide hemifumarate

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Catalog No. T7282Cas No. 1392275-56-7
Alias Tenofovir alafenamide fumarate, GS-7340 (hemifumarate)

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).

Tenofovir alafenamide hemifumarate
Other Forms of Tenofovir alafenamide hemifumarate:

Tenofovir alafenamide hemifumarate

🥰Excellent
Purity: 99.96%
Catalog No. T7282Alias Tenofovir alafenamide fumarate, GS-7340 (hemifumarate)Cas No. 1392275-56-7
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$39In StockIn Stock
10 mg$55In StockIn Stock
25 mg$86In StockIn Stock
50 mg$113In StockIn Stock
100 mg$155In StockIn Stock
500 mg$389In StockIn Stock
1 mL x 10 mM (in DMSO)$46In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
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Product Introduction

Bioactivity
Description
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).
In vitro
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).?Overexpression of CatA or liver carboxylesterase 1 (Ces1) in HEK293T cells increased intracellular TAF hydrolysis 2- and 5-fold, respectively.?Knockdown of CatA expression with RNA interference (RNAi) in HeLa cells reduced intracellular TAF metabolism 5-fold.?Additionally, the anti-HIV activity and the rate of CatA hydrolysis showed good correlation within a large set of TFV phosphonoamidate prodrugs[1].
SynonymsTenofovir alafenamide fumarate, GS-7340 (hemifumarate)
Chemical Properties
Molecular Weight534.51
FormulaC21H29N6O5P·1/2C4H4O4
Cas No.1392275-56-7
SmilesOC(/C=C/C(O)=O)=O.CC(C)OC([C@H](C)NP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(OC3=CC=CC=C3)=O)=O.CC(C)OC([C@H](C)NP(CO[C@H](C)CN4C5=NC=NC(N)=C5N=C4)(OC6=CC=CC=C6)=O)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (93.54 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.74 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8709 mL9.3544 mL18.7087 mL93.5436 mL
5 mM0.3742 mL1.8709 mL3.7417 mL18.7087 mL
10 mM0.1871 mL0.9354 mL1.8709 mL9.3544 mL
20 mM0.0935 mL0.4677 mL0.9354 mL4.6772 mL
50 mM0.0374 mL0.1871 mL0.3742 mL1.8709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tenofovir alafenamide hemifumarateTenofovir alafenamide HemifumarateTenofovir alafenamide FumarateTenofovir alafenamideReverseTranscriptaseReverse TranscriptaseInhibitorinhibitHuman immunodeficiency virusHIVProteaseHIV-1HIV ProteaseHIVGS-7340 hemifumarateGS-7340GS7340GS 7340
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