Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease research, specifically for conditions characterized by loss of cardiomyocytes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 128.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 422.00 | |
100 mg | In stock | $ 613.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease research, specifically for conditions characterized by loss of cardiomyocytes. |
In vitro | TT-10 (10 μmol/L ; 48 h) significantly promoted cell cycle activation and cell division of human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (hiPSCM).[1] |
In vivo | TT-10 (2 μM, 10 μM, 20 μM, or 100 μM ; 48 h ; intraperitoneal injections) was administered to infarcted mouse hearts, the treatment promoted cardiomyocyte proliferation and was associated with declines in infarct size 1 week after administration, but cardiac function worsened at later time points.[2] |
Synonyms | TAZ-K |
Molecular Weight | 283.35 |
Formula | C11H10FN3OS2 |
CAS No. | 2230640-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (38.82 mM)
You can also refer to dose conversion for different animals. More
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TT-10 2230640-94-3 Stem Cells YAP TT 10 TT10 TAZ-K inhibitor inhibit