CD70 Trimer Protein, Mouse, Recombinant (His)

Name: CD70 Trimer Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-07218
Rating: 4.5 (1 reviews)

(Synonyms: Tnlg8a, Tnfsf7, Cd70, CD27LG, Cd27l) Copy Product Info

Synonyms: Tnlg8a, Tnfsf7, Cd70, CD27LG, Cd27l

Catalog No. TMPY-07218 Copy Product Info

CD70 Trimer Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is O55237.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$109	7-10 days	7-10 days
20 µg	$172	7-10 days	7-10 days
50 µg	$343	7-10 days	7-10 days
100 µg	$682	7-10 days	7-10 days
200 µg	$987	7-10 days	7-10 days
500 µg	$2,200	7-10 days	7-10 days
1 mg	$4,500	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Recombinant Mouse CD70 protein (His Tag) at 2 μg/mL (100 μL/well) can bind Recombinant Mouse CD27 Protein (ECD, mFc Tag), the EC50 is 2.3-6.9 ng/mL.
Description	CD70 Trimer Protein, Mouse, Recombinant (His) is expressed in HEK293 Cells. The accession number is O55237.
Species	Mouse
Expression System	HEK293 Cells
Tag	N-His
Accession Number	O55237
Construction	A DNA sequence encoding the Mouse CD70 (NP_035747.1) (Gln47-Pro195) was expressed, with a polyhistidine tag at the N-terminus.
Protein Purity	≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile 25mM Sodium Citrate, 200mM NaCl, 10% Trehalose, 10% glycerol, pH 6.0. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Please refer to the lot-specific COA.
Synonyms	Tnlg8a, Tnfsf7, Cd70, CD27LG, Cd27l
Research Background	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

51.62 kDa (predicted); 87.6 kDa (reducing contition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.