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Oxythiamine chloride HCl

Name: Oxythiamine chloride HCl
Brand: TargetMol
SKU: T71783
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Oxythiamine chloride hydrochloride, Hydroxythiamine chloride hydrochloride) Copy Product Info

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Synonyms: Oxythiamine chloride hydrochloride, Hydroxythiamine chloride hydrochloride

Catalog No. T71783 Copy Product Info

Purity: 99.79%

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Oxythiamine chloride HCl is an antimetabolite analog that can inhibit the non-oxidative synthesis pathway of ribose. As a thiamine antagonist, Oxythiamine chloride HCl inhibits transketolase. Oxythiamine chloride HCl can inhibit the proliferation of tumor cells and regulate the apoptosis of cancer cells.

Cas No. 614-05-1

Pack Size	Price	USA Stock	Global Stock
50 mg	$31	-	In Stock
100 mg	$48	-	In Stock
1 mL x 10 mM (in DMSO)	$35	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.79%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Oxythiamine chloride HCl is an antimetabolite analog that can inhibit the non-oxidative synthesis pathway of ribose. As a thiamine antagonist, Oxythiamine chloride HCl inhibits transketolase. Oxythiamine chloride HCl can inhibit the proliferation of tumor cells and regulate the apoptosis of cancer cells.
Targets & IC50	DNA synthesis (Mia Paca-2 cells):14.95 μM
In vitro	Methods: MIA PaCa-2 cells were treated with Oxythiamine chloride HCl (0–40 μM) for 2 days. Results: Oxythiamine chloride HCl inhibited the viability of MIA PaCa-2 cells, with an IC50 of 14.95 μM. Methods: MIA PaCa-2 cells were treated with Oxythiamine chloride HCl (0–500 μM) for 48 hours. Results: Oxythiamine chloride HCl inhibited the expression of 14-3-3 protein beta/alpha in MIA PaCa-2 cells [1]. Methods: A549 cells were treated with Oxythiamine chloride HCl (0.1–100 μM) for 6–48 h. Results: Oxythiamine chloride HCl inhibited the proliferation of A549 cells. Methods: A549 cells were treated with Oxythiamine chloride HCl (0.1–100 μM) for 24 h. Results: Oxythiamine chloride HCl induced apoptosis in A549 cells [3]. Methods: Lewis lung cancer (LLC) cells were treated with Oxythiamine chloride HCl (0–20 μM). Results: Oxythiamine chloride HCl inhibited the invasion and migration of Lewis lung cancer (LLC) cells, with an IC50 of 8.75 μM [4].
In vivo	Methods: Ehrlich ascites tumor-bearing mice were intraperitoneally injected with Oxythiamine chloride HCl (100–500 mg/kg, i.p.) for 4 consecutive days. Results: Oxythiamine chloride HCl inhibited tumor growth in Ehrlich ascites tumor-bearing mice [2]. Methods: Mice subcutaneously implanted with LLC cells were intraperitoneally injected with Oxythiamine chloride HCl (250 or 500 mg/kg) once daily for 5 consecutive weeks. Results: Oxythiamine chloride HCl inhibited tumor cell metastasis by suppressing the expression of MMPs in mice [4].
Synonyms	Oxythiamine chloride hydrochloride, Hydroxythiamine chloride hydrochloride

Chemical Properties

Molecular Weight	338.25
Formula	C₁₂H₁₇Cl₂N₃O₂S
Cas No.	614-05-1
Smiles	[Cl-].Cl.O=C1NC(=NC=C1C[N+]2=CSC(=C2C)CCO)C

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (236.51 mM), Sonication is recommended.

DMSO: 40 mg/mL (118.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.9564 mL	14.7820 mL	29.5639 mL	147.8197 mL
5 mM	0.5913 mL	2.9564 mL	5.9128 mL	29.5639 mL
10 mM	0.2956 mL	1.4782 mL	2.9564 mL	14.7820 mL
20 mM	0.1478 mL	0.7391 mL	1.4782 mL	7.3910 mL
50 mM	0.0591 mL	0.2956 mL	0.5913 mL	2.9564 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	1.4782 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Oxythiamine chloride HCl chemical structure | Oxythiamine chloride HCl in vivo | Oxythiamine chloride HCl in vitro | Oxythiamine chloride HCl formula | Oxythiamine chloride HCl molecular weight