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MS9427
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Catalog No. T74633Cas No. 2772613-37-1
MS9427 is a potent PROTAC EGFR degrader with dissociation constants (K d s) of 7.1 nM for wild-type (WT) EGFR and 4.3 nM for L858R mutant EGFR, demonstrating selective degradation of the mutant via ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 effectively inhibits non-small cell lung cancer (NSCLC) cell proliferation, positioning it as a potential therapeutic agent in anticancer research [1].
MS9427
😃Good
Catalog No. T74633Cas No. 2772613-37-1
MS9427 is a potent PROTAC EGFR degrader with dissociation constants (K d s) of 7.1 nM for wild-type (WT) EGFR and 4.3 nM for L858R mutant EGFR, demonstrating selective degradation of the mutant via ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 effectively inhibits non-small cell lung cancer (NSCLC) cell proliferation, positioning it as a potential therapeutic agent in anticancer research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MS9427 is a potent PROTAC EGFR degrader with dissociation constants (K d s) of 7.1 nM for wild-type (WT) EGFR and 4.3 nM for L858R mutant EGFR, demonstrating selective degradation of the mutant via ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 effectively inhibits non-small cell lung cancer (NSCLC) cell proliferation, positioning it as a potential therapeutic agent in anticancer research [1]. |
| Targets&IC50 | EGFR L858R:4.3 nM (Kd), EGFR (WT):7.1 nM (Kd) |
| Molecular Weight | 993.47 |
| Formula | C48H58ClFN8O12 |
| Cas No. | 2772613-37-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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